XRCC4: X-ray repair cross complementing 4
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1fu1 chain A
1fu1 chain B
1ik9 chain A
1ik9 chain B
3ii6 chain A
3ii6 chain B
3ii6 chain C
3ii6 chain D
3mud chain A
3mud chain B
3q4f chain C
3q4f chain D
3q4f chain G
3q4f chain H
3rwr chain A
3rwr chain B
3rwr chain F
3rwr chain G
3rwr chain J
3rwr chain K
3rwr chain N
3rwr chain P
3rwr chain R
3rwr chain U
3rwr chain V
3rwr chain Y
3sr2 chain A
3sr2 chain B
3sr2 chain E
3sr2 chain F
3w03 chain C
3w03 chain D
4xa4 chain A
4xa4 chain B
5chx chain A
5chx chain B
5cj0 chain A
5cj0 chain B
5cj4 chain A
5cj4 chain B
5cj4 chain C
5cj4 chain D
5e50 chain C
5e50 chain D
5wj7 chain A
5wj7 chain B
5wlz chain A
5wlz chain B
5wlz chain C
5wlz chain D
6abo chain A
7lsy chain F
7lsy chain G
7lsy chain O
7lsy chain P
7lt3 chain F
7lt3 chain G
7lt3 chain O
7lt3 chain P
7m3p chain A
7m3p chain B
7nfc chain K
7nfc chain L
7nfc chain N
7nfc chain O
7nfe chain H
7nfe chain I
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S219 EGETAICS EMTADRD 2 16 - - - - - - - - - - 5 4 - - - - - - 7 - T222 TAICSEMT ADRDPVY 5 40 - - 3 3 - - - - 6 4 5 4 4 4 - - - - 5 2 Y229 TADRDPVY DESTDEE 2 22 - - 8 6 - - - - - - - - 4 4 - - - - - - S232 RDPVYDES TDEESEN 8 158 9 - 4 4 - - 28 - 6 3 5 4 18 16 - - 12 4 31 14 T233 DPVYDEST DEESENQ 8 169 6 - 9 8 - - 8 - 40 22 5 4 5 4 - - 5 2 42 9 S237 DESTDEES ENQTDLS 8 514 33 - 36 24 - - 63 - 76 42 34 32 49 45 - - 19 8 48 5 T241 DEESENQT DLSGLAS 8 124 14 - 16 16 - - 9 - 16 12 5 2 5 4 - - 6 4 10 5 S244 SENQTDLS GLASAAV 3 25 8 - 4 4 - - - - - - - - - - - - - - - 9 S256 AAVSKDDS IISSLDV 7 402 - - 8 8 - - 90 - 64 37 5 4 27 24 - - 30 15 72 18 S259 SKDDSIIS SLDVTDI 5 49 - - 5 4 - - 9 - - - - - 5 4 - - 9 5 6 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S219 EGETAICS EMTADRD - - - - - - - - - - - T222 TAICSEMT ADRDPVY - - - - - - - - - - - Y229 TADRDPVY DESTDEE - - - - - - - - - - - S232 RDPVYDES TDEESEN 0.86 - - - - - - - - - 0.86 T233 DPVYDEST DEESENQ 0.033 - - - - 0.033 - - - - - S237 DESTDEES ENQTDLS 0.011 - -0.36 - - -0.92 3.4e-3 1.7e-3 - - - T241 DEESENQT DLSGLAS - - - - - - - - - - - S244 SENQTDLS GLASAAV - - - - - - - - - - - S256 AAVSKDDS IISSLDV 1.1e-3 - - - - 1.3e-4 - 0.69 - 8.5e-3 -0.73 S259 SKDDSIIS SLDVTDI - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S219
T222
Y229
S232
T233
S237
T241
S244
S256
S259
S260
T264
S299
S303
S304
S320
T323
S327
S328
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation CCRCC S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation COAD S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation GBM S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation HNSCC S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation LSCC S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation LUAD S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation OV S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation PDAC S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation UCEC S219 T222 Y229 S232 T233 S237 T241 S244 S256 S259 S260 T264 S299 S303 S304 S320 T323 S327 S328 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S219
T222
Y229
S232
T233
S237
T241
S244
S256
S259
S260
T264
S299
S303
S304
S320
T323
S327
S328
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S219
T222
Y229
S232
T233
S237
T241
S244
S256
S259
S260
T264
S299
S303
S304
S320
T323
S327
S328
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.