UIMC1: ubiquitin interaction motif containing 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2mkf chain A
2mkg chain A
2n9e chain A
2rr9 chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S29 VETTSSVS VKRKRRL 4 41 - - 4 2 - - - - - - 5 5 5 4 - - 11 5 - - S44 EDAFIVIS DSDGEEP 9 652 40 - 37 25 82 88 54 - 34 22 30 28 21 21 - - 89 37 28 16 S46 AFIVISDS DGEEPKE 9 519 9 - 29 20 4 5 9 - 70 38 64 58 31 28 - - 89 37 23 5 S101 QEAREVNS QEEEEEE 9 853 32 - 40 39 - - 18 - 103 58 88 80 77 67 76 17 80 31 43 4 S127 SCRPSDAS ATRSRPL 3 76 - - 9 8 - - - - - - - - 27 24 - - - - 6 2 S140 PLATGPSS QSHQEKT 8 249 35 - 4 4 6 3 - - 56 34 20 17 23 19 14 2 8 4 - - S142 ATGPSSQS HQEKTTD 1 13 - - - - - - - - - - - - - - - - 10 3 - - S171 LFKGSHIS QGNEAEE 6 187 8 - - - 31 32 - - - - 10 9 5 4 68 14 - - 6 - S198 EEPVSGSS GSWDQSS 1 14 - - - - - - - - - - - - - - - - - - 14 - S200 PVSGSSGS WDQSSQP 4 64 - - - - - - - - 6 4 - - 5 4 9 1 - - 31 4
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S29 VETTSSVS VKRKRRL - - - - - - - - - - - S44 EDAFIVIS DSDGEEP 1.2e-4 - -0.085 3.4e-4 - 0.029 7.2e-4 5.2e-3 - -2.3e-3 2.8e-3 S46 AFIVISDS DGEEPKE 0.1 - -0.21 - - -0.43 5.8e-9 3.3e-3 - -2.3e-3 - S101 QEAREVNS QEEEEEE 1.5e-57 - 7e-12 - - 1.4e-11 7.8e-23 1.4e-15 0.15 3.5e-10 - S127 SCRPSDAS ATRSRPL 1.2e-4 - - - - - - 1.2e-4 - - - S140 PLATGPSS QSHQEKT 5e-23 - - - - 8.3e-11 1.7e-8 6.2e-7 - - - S142 ATGPSSQS HQEKTTD - - - - - - - - - - - S171 LFKGSHIS QGNEAEE 1.9e-8 - - 3.8e-4 - - - - 1.1e-5 - - S198 EEPVSGSS GSWDQSS - - - - - - - - - - - S200 PVSGSSGS WDQSSQP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S29
S44
S46
S101
S127
S140
S142
S171
S198
S200
S204
S205
S224
S330
S343
S350
S380
S402
S415
T426
S427
S430
T443
T448
S451
S463
S466
S554
S597
S602
S627
S632
T646
S653
S677
S705
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation CCRCC S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation COAD S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation GBM S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation HNSCC S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation LSCC S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation LUAD S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation OV S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation PDAC S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation UCEC S29 S44 S46 S101 S127 S140 S142 S171 S198 S200 S204 S205 S224 S330 S343 S350 S380 S402 S415 T426 S427 S430 T443 T448 S451 S463 S466 S554 S597 S602 S627 S632 T646 S653 S677 S705 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S29
S44
S46
S101
S127
S140
S142
S171
S198
S200
S204
S205
S224
S330
S343
S350
S380
S402
S415
T426
S427
S430
T443
T448
S451
S463
S466
S554
S597
S602
S627
S632
T646
S653
S677
S705
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S29
S44
S46
S101
S127
S140
S142
S171
S198
S200
S204
S205
S224
S330
S343
S350
S380
S402
S415
T426
S427
S430
T443
T448
S451
S463
S466
S554
S597
S602
S627
S632
T646
S653
S677
S705
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.