Protein: ENSP00000422168
Gene: SH3BP2

LinkedOmicsKB © 2022-2023 Zhang Lab

SH3BP2:
SH3 domain binding protein 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S225SDMPRAHSFTSKGPG8830----899099-422339373030831995419518
S278PATPRRMSDPPLSTM10146097-8764798299-10862108991101018319105449518
S336RNCDKLKSFHLSPRG353------36-------71--72
S340KLKSFHLSPRGPPTS18--------------71----
S416QLPHLQRSPPDGQSF101452105-10380828899-96561089910293761895399518
S425PDGQSFRSFSFEKPR235------26-----------72
S427GQSFRSFSFEKPRQP518360---352826-------187--72
S435FEKPRQPSQADTGGD227----------5598------
T439RQPSQADTGGDDSDE594--2112----151155108--52--
S444ADTGGDDSDEDYEKV10136588-9976878399-108621089910293114105448215
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S225SDMPRAHSFTSKGPG1.3e-3--0.1-0.73-0.0462.2e-38.1e-33.9e-5-0.2
S278PATPRRMSDPPLSTM-0.21-3.3e-5-2.8e-11-0.017-3.3e-4-0.73-5.2e-33.1e-8-0.025
S336RNCDKLKSFHLSPRG-----------
S340KLKSFHLSPRGPPTS-----------
S416QLPHLQRSPPDGQSF9.6e-5-1.7e-87.1e-12--1-0.250.001-2.8e-30.029-5.5e-3
S425PDGQSFRSFSFEKPR-----------
S427GQSFRSFSFEKPRQP-0.038---0.038-------
S435FEKPRQPSQADTGGD-----------
T439RQPSQADTGGDDSDE1.5e-3-1.5e-3--------
S444ADTGGDDSDEDYEKV-1.5e-3--0.510.97--0.31-0.160.88--0.039-5.9e-4
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_TNFA_SIGNALING_VIA_NFKBS4162.4e-230.230.230.0323.7e-70.0124.5e-91.1e-62.1e-30.0921.3e-4
KINASE-PSP_PKACA/PRKACAS2783.2e-203.6e-30.260.34.6e-73.7e-31.2e-60.424.9e-52.4e-46.8e-3
KINASE-PSP_PKCA/PRKCAS2254.1e-20--2.5e-46.9e-50.0524.1e-50.0331.5e-40.242.2e-7
PERT-PSP_EGFS2781.4e-190.270.254.8e-44.0e-52.9e-78.5e-60.0449.9e-39.8e-40.19
PROGENy: NFkBS4165.4e-180.59-0.0660.0287.7e-73.3e-31.5e-86e-70.0139.5e-34.7e-3
PROGENy: TNFaS4161.8e-170.56-0.0360.045.8e-75.9e-31.5e-92.0e-60.0170.0113.8e-3
HALLMARK_INFLAMMATORY_RESPONSES4162.8e-170.46-0.0810.0142.8e-60.0392.4e-111.7e-50.0220.0441.1e-3
PERT-PSP_PHORBOL_ESTERS2787.4e-15--9.1e-51.4e-39.7e-80.0110.10.683.4e-30.042
HALLMARK_APOPTOSISS4165e-140.530.760.71.9e-50.0515.1e-85.8e-43.1e-30.521.4e-4
KINASE-PSP_PKACA/PRKACAS2256.1e-14--0.0241.5e-50.241.6e-40.253.3e-4-0.893.7e-7
Showing 1 to 10 of 2580 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationCCRCCS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationCOADS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationGBMS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationHNSCCS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationLSCCS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationLUADS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationOVS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationPDACS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylationUCECS225S278S336S340S416S425S427S435T439S444proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.