NSD2: nuclear receptor binding SET domain protein 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5lsu chain A
5lsu chain B
5vc8 chain A
5vc8 chain B
6ue6 chain A
6ue6 chain B
6ue6 chain C
6ue6 chain D
6ue6 chain E
6ue6 chain F
6ue6 chain G
6ue6 chain H
6xcg chain A
6xcg chain B
6xcg chain C
7cro chain I
7e8d chain K
7lmt chain A
7lmt chain B
7lmt chain C
7lmt chain D
7lmt chain E
7lmt chain F
7lmt chain G
7lmt chain H
7mdn chain A
7mdn chain B
7mdn chain C
7mdn chain D
7mdn chain E
7mdn chain F
7mdn chain G
7mdn chain H
7vln chain A
7vln chain B
7vln chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S8 MEFSIKQS PLSVQSV 1 8 8 - - - - - - - - - - - - - - - - - - - S11 SIKQSPLS VQSVVKC 1 8 8 - - - - - - - - - - - - - - - - - - - S14 QSPLSVQS VVKCIKM 1 8 8 - - - - - - - - - - - - - - - - - - - S30 QAPEILGS ANGKTPS 1 6 6 - - - - - - - - - - - - - - - - - - - T35 LGSANGKT PSCEVNR 2 30 - - - - - - - - - - - - 8 8 - - - - 12 2 S56 SKAQLSSS LQEGVMQ 3 48 8 - - - - - 9 - - - - - - - - - - - 18 13 S102 DAKLRFES QEMKGIG 1 8 - - - - - - - - - - 4 4 - - - - - - - - T110 QEMKGIGT PPNTTPI 7 146 15 - 4 2 - - 18 - 11 7 5 4 - - 14 2 - - 48 16 T114 GIGTPPNT TPIKNGS 7 146 13 - 8 8 - - 18 - 12 6 20 19 5 4 - - - - 17 16 T115 IGTPPNTT PIKNGSP 9 588 40 - 8 8 - - 90 - 16 10 49 44 65 59 45 8 28 11 89 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S8 MEFSIKQS PLSVQSV - - - - - - - - - - - S11 SIKQSPLS VQSVVKC - - - - - - - - - - - S14 QSPLSVQS VVKCIKM - - - - - - - - - - - S30 QAPEILGS ANGKTPS - - - - - - - - - - - T35 LGSANGKT PSCEVNR - - - - - - - - - - - S56 SKAQLSSS LQEGVMQ - - - - - - - - - - - S102 DAKLRFES QEMKGIG - - - - - - - - - - - T110 QEMKGIGT PPNTTPI -0.76 - - - - - - - - - -0.76 T114 GIGTPPNT TPIKNGS 1.7e-4 - - - - - 1.7e-4 - - - - T115 IGTPPNTT PIKNGSP 2.5e-26 - - - - - 2.2e-21 3.2e-17 - 0.94 1.3e-3
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S8
S11
S14
S30
T35
S56
S102
T110
T114
T115
S121
S172
S194
S389
S407
S408
T422
S437
T544
S555
S604
T605
T649
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation CCRCC S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation COAD S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation GBM S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation HNSCC S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation LSCC S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation LUAD S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation OV S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation PDAC S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation UCEC S8 S11 S14 S30 T35 S56 S102 T110 T114 T115 S121 S172 S194 S389 S407 S408 T422 S437 T544 S555 S604 T605 T649 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S8
S11
S14
S30
T35
S56
S102
T110
T114
T115
S121
S172
S194
S389
S407
S408
T422
S437
T544
S555
S604
T605
T649
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S8
S11
S14
S30
T35
S56
S102
T110
T114
T115
S121
S172
S194
S389
S407
S408
T422
S437
T544
S555
S604
T605
T649
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.