Protein: ENSP00000424417
Gene: PLRG1

LinkedOmicsKB © 2022-2023 Zhang Lab

PLRG1:
pleiotropic regulator 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S39PVPLDEESHKRKMAI18--44----------------
S119TKIQRMPSESAAQSL10114498-9069282673-1015910899110101815019959
S121IQRMPSESAAQSLAV18----17--------------
S463PGSLDSESGIFACAF18--44----------------
Showing 1 to 4 of 4 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S39PVPLDEESHKRKMAI-----------
S119TKIQRMPSESAAQSL1e-8-3.0e-40.21--6.1e-88.3e-93e-12-0.067-
S121IQRMPSESAAQSLAV-----------
S463PGSLDSESGIFACAF-----------
Showing 1 to 4 of 4 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_MAPKAPK2S1191.6e-13--0.170.499.2e-42.2e-16--1.7e-40.48
PERT-PSP_NOCODAZOLES1193.6e-81.2e-30.160.140.3-0.840.0141.5e-3-0.333.1e-3
KINASE-PSP_Chk1/CHEK1S1191.1e-6---0.710.62-0.910.0485.7e-10-0.0743.5e-3
chromosomal instabilityS1194.2e-60.112.7e-40.048-0.810.960.686.1e-5-0.018-0.97
HALLMARK_GLYCOLYSISS1194.9e-56.0e-43.2e-4-0.960.090.970.160.051--0.730.65
PERT-P100-DIA_STAUROSPORINES1196.0e-5-0.54--0.0341.6e-40.24-2.9e-5-4.4e-41.4e-6
PERT-PSP_EGFS1197.7e-50.0241.7e-40.320.022-0.470.083-0.75-0.04-0.85
KINASE-PSP_CDK2S1191.0e-48.1e-40.280.46-0.11-0.0625.2e-42.7e-5-0.90.028
KINASE-PSP_AurB/AURKBS1191.1e-4---0.0270.40.060.45-8.5e-40.66
PERT-P100-DIA_SEMAGACESTATS1191.4e-3---4.6e-3-0.09----
Showing 1 to 10 of 1032 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS39S119S121S463proteinRNASCNVmethylationCCRCCS39S119S121S463proteinRNASCNVmethylationCOADS39S119S121S463proteinRNASCNVmethylationGBMS39S119S121S463proteinRNASCNVmethylationHNSCCS39S119S121S463proteinRNASCNVmethylationLSCCS39S119S121S463proteinRNASCNVmethylationLUADS39S119S121S463proteinRNASCNVmethylationOVS39S119S121S463proteinRNASCNVmethylationPDACS39S119S121S463proteinRNASCNVmethylationUCECS39S119S121S463proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
GSK3BS1195.7e-80.0130.50.34-0.241.4e-60.330.047-3.2e-38.8e-3
CDK5S1193.3e-60.653.1e-40.19-0.450.260.180.17-1.7e-50.24
CASKS1193.7e-6-0.590.110.01-0.20.10.140.087-1.9e-42.7e-3
NRBP1S1195.8e-60.059-0.440.450.0856.1e-70.420.78-6.8e-5-0.96
RPS6KA3S1198.0e-61.9e-30.12-0.845.3e-30.31.4e-30.71-0.014-0.36
CAMK2DS1191.7e-50.012-0.640.440.380.0160.510.3-0.0352.4e-3
PRKAA1S1191.4e-40.0840.260.220.0340.50.140.81-0.380.047
RIPK2S1191.5e-40.0720.30.210.0990.110.66-0.6-0.0740.02
IRAK1S1192.1e-47.8e-30.043-0.550.620.0380.110.16-0.1-0.88
MAP2K2S1192.5e-40.0960.210.7917.0e-5-0.11-0.33-3.9e-44.6e-3
Showing 1 to 10 of 2152 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
INPP5AS119-2.9e-6-0.015-3.6e-40.13-0.079-0.056-0.5-0.14--0.01-0.24
G6PC3S119-9.8e-6-0.13-0.007-0.98-0.29-9.8e-3-0.840.71--4.1e-4-0.041
PPP3CCS119-5.0e-5-0.91-0.21--0.46-0.084-0.12-9.4e-3--9.5e-3-0.37
DUSP22S119-7.1e-50.3-4.5e-3-0.810.48-0.79-0.024-4.6e-3--0.22-6.8e-5
PTPRBS119-3.7e-4-0.31-0.014--0.35-2.1e-3-0.78-0.75--0.19-
PPP1CCS119-7.7e-4-0.10.9-0.36-0.2-4.3e-40.72-0.081--0.0920.82
INPP5KS119-7.8e-4-0.42-0.91-0.05-0.11-0.11-0.39-0.056--0.0230.28
CTDP1S119-1.1e-30.340.77-0.71-0.14-0.038-0.59-6.9e-4--0.56-0.009
PTPN9S119-1.1e-3-0.11-0.74-0.220.17-0.095-0.81-2.0e-4--0.49-0.1
CTDSPL2S119-1.2e-3-0.44-0.0410.88-0.16-0.0790.95-0.2--0.052-0.45
Showing 1 to 10 of 960 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.