HSD17B4: hydroxysteroid 17-beta dehydrogenase 4
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ikt chain A
1s9c chain A
1s9c chain B
1s9c chain C
1s9c chain D
1s9c chain E
1s9c chain F
1s9c chain G
1s9c chain H
1s9c chain I
1s9c chain J
1s9c chain K
1s9c chain L
1zbq chain A
1zbq chain B
1zbq chain C
1zbq chain D
1zbq chain E
1zbq chain F
6z1w chain A
6z1x chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S52 FKGVGKGS LAADKVV 3 123 - - 16 16 - - - - - - 30 27 18 16 - - - - - - S112 DRSFARIS DEDWDII 1 9 - - - - - - 9 - - - - - - - - - - - - - S185 LAIEGRKS NIHCNTI 3 141 - - 4 4 - - - - - - 30 28 40 35 - - - - - - S198 TIAPNAGS RMTQTVM 5 263 - - - - - - 62 - 12 7 63 56 31 27 - - 3 2 - - T265 RQKNHPMT PEAVKAN 9 1163 - - 87 64 60 48 99 - 68 38 108 99 110 101 56 12 84 34 77 18 S287 ENASKPQS IQESTGS 6 299 - - 4 4 - - 9 - 33 20 60 54 56 53 - - 5 1 - - S291 KPQSIQES TGSIIEV 5 273 - - 50 29 12 6 - - - - 53 49 35 33 - - - - 6 - T292 PQSIQEST GSIIEVL 7 177 - - 39 29 - - 9 - 11 5 24 22 9 8 - - 9 4 8 - S294 SIQESTGS IIEVLSK 8 930 - - 86 66 29 16 72 - 108 62 94 86 110 101 - - 22 8 52 18 S300 GSIIEVLS KIDSEGG 3 41 - - - - - - - - - - 5 5 4 4 - - - - 19 4
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S52 FKGVGKGS LAADKVV -2.8e-14 - - - - - -2.8e-14 - - - - S112 DRSFARIS DEDWDII - - - - - - - - - - - S185 LAIEGRKS NIHCNTI -9.5e-3 - - - - - -1.6e-4 0.91 - - - S198 TIAPNAGS RMTQTVM -4.9e-7 - - - - - -2.2e-9 -0.26 - - - T265 RQKNHPMT PEAVKAN -0.25 - 1.6e-3 1.1e-6 - -0.02 -3e-15 -0.18 0.24 0.27 6.9e-6 S287 ENASKPQS IQESTGS -1.6e-21 - - - - -0.49 -2.2e-15 -3e-15 - - - S291 KPQSIQES TGSIIEV -2.1e-13 - -0.3 - - - -2.1e-13 -1.4e-5 - - - T292 PQSIQEST GSIIEVL -1.5e-4 - 0.86 - - - -3e-8 - - - - S294 SIQESTGS IIEVLSK -4.0e-5 - 1.3e-4 0.016 - -2.5e-4 -4.4e-11 -1.5e-14 - - 0.1 S300 GSIIEVLS KIDSEGG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S52
S112
S185
S198
T265
S287
S291
T292
S294
S300
S304
S309
T313
S314
T317
S318
T319
S322
S369
S398
T593
Y602
T608
S612
T615
S617
S624
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation CCRCC S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation COAD S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation GBM S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation HNSCC S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation LSCC S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation LUAD S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation OV S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation PDAC S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation UCEC S52 S112 S185 S198 T265 S287 S291 T292 S294 S300 S304 S309 T313 S314 T317 S318 T319 S322 S369 S398 T593 Y602 T608 S612 T615 S617 S624 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S52
S112
S185
S198
T265
S287
S291
T292
S294
S300
S304
S309
T313
S314
T317
S318
T319
S322
S369
S398
T593
Y602
T608
S612
T615
S617
S624
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S52
S112
S185
S198
T265
S287
S291
T292
S294
S300
S304
S309
T313
S314
T317
S318
T319
S322
S369
S398
T593
Y602
T608
S612
T615
S617
S624
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.