Protein: ENSP00000425979
Gene: DROSHA

LinkedOmicsKB © 2022-2023 Zhang Lab

DROSHA:
drosha ribonuclease III

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S217YPLPKAPSERRSPER4191------52---1514----33134816
S221KAPSERRSPERLKHY834761-44464917-80441514----4252
S246GRGERHRSLDRRERG223----------97------52
S300RHRDNRRSPSLERSY773070---626318-86499890----81365918
S302RDNRRSPSLERSYKK887870---626399-864998903631--81365918
S317EYKRSGRSYGLSVVP199-------------------
S355LEIVNHRSPSREKKR997496-704881090-9855108986964--60255916
S357IVNHRSPSREKKRAR962347-331481055-341664587468--69283114
S373EEEKDRWSDNQSSGK855147-1210--37-362083754138--5120729
S807LRHLLANSPKVKQTD216--44--------44------
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S217YPLPKAPSERRSPER0.083--------0.140.32
S221KAPSERRSPERLKHY8.3e-12--4.1e-4-8.9e-10-----
S246GRGERHRSLDRRERG-----------
S300RHRDNRRSPSLERSY7.5e-28--3.1e-10-4.2e-182.5e-31---5.3e-80.001
S302RDNRRSPSLERSYKK7.8e-37--3.1e-10-4.2e-182.5e-314.3e-11--5.3e-80.001
S317EYKRSGRSYGLSVVP-----------
S355LEIVNHRSPSREKKR3.6e-11--5.5e-3--0.733e-211.5e-10-0.370.06
S357IVNHRSPSREKKRAR6.6e-7-7.7e-4---0.0361.3e-113e-10--0.17-0.44
S373EEEKDRWSDNQSSGK6.7e-10----8.3e-33.3e-226e-7--6.4e-7-
S807LRHLLANSPKVKQTD-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationCCRCCS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationCOADS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationGBMS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationHNSCCS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationLSCCS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationLUADS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationOVS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationPDACS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylationUCECS217S221S246S300S302S317S355S357S373S807proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.