ABL2: ABL proto-oncogene 2, non-receptor tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ecd chain A
2kk1 chain A
2xyn chain A
2xyn chain B
2xyn chain C
3gvu chain A
3hmi chain A
3ulr chain C
4eih chain A
5np3 chain A
5np3 chain B
5np3 chain C
5np3 chain D
5np5 chain A
5np5 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S26 PRGIRGSS AARPSGR 1 8 - - - - - - 8 - - - - - - - - - - - - - S31 GSSAARPS GRRRDPA 5 244 - - - - - - 61 - - - 34 30 40 35 - - 25 10 - 9 S72 GDKTGGSS PEALHRP 7 415 - - 11 11 - - 98 - 21 12 59 53 48 45 - - 11 6 24 16 Y80 PEALHRPY GCDVEPQ 1 9 - - - - - - - - - - - - 4 5 - - - - - - Y116 PNLFVALY DFVASGD 1 8 - - 4 4 - - - - - - - - - - - - - - - - Y231 TTADGKVY VTAESRF 1 18 - - - - - - 18 - - - - - - - - - - - - - S275 KPTVYGVS PIHDKWE 1 27 - - - - - - 27 - - - - - - - - - - - - - S602 AQDATENS ASSLAPG 7 846 - - 83 60 - - 90 - 45 28 103 94 94 86 - - 43 16 86 18 S618 IRGAQASS GSPALPR 2 29 - - - - - - - - - - - - - - - - 13 6 10 - S620 GAQASSGS PALPRKQ 7 936 - - 64 43 - - 99 - 72 44 108 99 93 83 - - 95 39 79 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S26 PRGIRGSS AARPSGR - - - - - - - - - - - S31 GSSAARPS GRRRDPA 0.017 - - - - - 0.03 5.1e-6 - -9.5e-3 - S72 GDKTGGSS PEALHRP 9.2e-3 - - - - 0.43 0.08 0.44 - - 0.058 Y80 PEALHRPY GCDVEPQ - - - - - - - - - - - Y116 PNLFVALY DFVASGD - - - - - - - - - - - Y231 TTADGKVY VTAESRF - - - - - - - - - - - S275 KPTVYGVS PIHDKWE - - - - - - - - - - - S602 AQDATENS ASSLAPG 0.037 - 1.2e-8 - - -0.94 0.38 0.13 - -0.014 -0.65 S618 IRGAQASS GSPALPR - - - - - - - - - - - S620 GAQASSGS PALPRKQ 8e-12 - 7.3e-7 - - 4.2e-5 5.0e-6 6.0e-4 - -1.2e-3 3.2e-3
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S26
S31
S72
Y80
Y116
Y231
S275
S602
S618
S620
S631
S654
S655
S669
S671
T753
S781
S783
T784
S786
S817
T818
S819
S820
T864
S866
S915
S936
S997
S1000
S1054
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation CCRCC S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation COAD S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation GBM S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation HNSCC S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation LSCC S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation LUAD S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation OV S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation PDAC S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation UCEC S26 S31 S72 Y80 Y116 Y231 S275 S602 S618 S620 S631 S654 S655 S669 S671 T753 S781 S783 T784 S786 S817 T818 S819 S820 T864 S866 S915 S936 S997 S1000 S1054 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S26
S31
S72
Y80
Y116
Y231
S275
S602
S618
S620
S631
S654
S655
S669
S671
T753
S781
S783
T784
S786
S817
T818
S819
S820
T864
S866
S915
S936
S997
S1000
S1054
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S26
S31
S72
Y80
Y116
Y231
S275
S602
S618
S620
S631
S654
S655
S669
S671
T753
S781
S783
T784
S786
S817
T818
S819
S820
T864
S866
S915
S936
S997
S1000
S1054
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.