PIK3R1: phosphoinositide-3-kinase regulatory subunit 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1a0n chain A
1azg chain A
1h9o chain A
1pbw chain A
1pbw chain B
1pht chain A
1pic chain A
1pks chain A
1pkt chain A
2iug chain A
2iuh chain A
2iui chain A
2iui chain B
2rd0 chain B
2v1y chain B
3hhm chain B
3hiz chain B
3i5r chain A
3i5s chain A
3i5s chain B
3i5s chain C
3i5s chain D
4a55 chain B
4jps chain B
4l1b chain B
4l23 chain B
4l2y chain B
4ovu chain B
4ovv chain B
4waf chain B
4ykn chain A
4zop chain B
5aul chain A
5fi4 chain B
5gji chain A
5itd chain B
5m6u chain B
5sw8 chain B
5swg chain B
5swo chain B
5swp chain B
5swr chain B
5swt chain B
5sx8 chain B
5sx9 chain B
5sxa chain B
5sxb chain B
5sxc chain B
5sxd chain B
5sxe chain B
5sxf chain B
5sxi chain B
5sxj chain B
5sxk chain B
5ubt chain B
5uk8 chain B
5ukj chain B
5ul1 chain B
5vlr chain B
5xgh chain B
5xgi chain B
5xgj chain B
6nct chain B
6pyr chain B
6pyu chain B
7cio chain A
7lm2 chain B
7lq1 chain B
7myn chain B
7myo chain B
7pg5 chain B
7pg6 chain B
7rns chain A
7tz7 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S36 ILTVNKGS LVALGFS 3 34 - - 9 8 - - - - - - 4 4 5 4 - - - - - - S43 SLVALGFS DGQEARP 4 89 24 - - - - - 18 - - - 20 18 5 4 - - - - - - S83 YIGRKKIS PPTPKPR 5 256 - - - - - - 81 - 68 41 15 15 - - - - 22 8 6 - T86 RKKISPPT PKPRPPR 3 69 - - - - - - 10 - - - - - - - - - 21 13 25 - S154 STLYRTQS SSNLAEL 9 531 14 - 21 17 32 31 46 - 6 4 84 78 38 32 - - 26 9 84 9 S265 LLNARVLS EIFSPML 1 8 - - - - - - - - - - - - - - - - - - 8 - Y452 VGKKLHEY NTQFQEK 8 562 - - 71 51 - - 28 - 27 16 60 56 75 68 15 2 33 12 37 11 Y467 SREYDRLY EEYTRTS 3 57 - - - - - - - - 23 11 4 4 - - - - 11 4 - - Y556 LKKQAAEY REIDKRM 7 788 - - 61 41 - - 99 - 43 27 108 99 87 81 - - 75 34 33 - T576 DLIQLRKT RDQYLMW 1 10 - - - - - - - - - - 5 5 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S36 ILTVNKGS LVALGFS - - - - - - - - - - - S43 SLVALGFS DGQEARP -2.9e-3 - - - - - -2.9e-3 - - - - S83 YIGRKKIS PPTPKPR 0.51 - - - - 0.51 - - - - - T86 RKKISPPT PKPRPPR -5.7e-6 - - - - - - - - -5.7e-6 - S154 STLYRTQS SSNLAEL 1.3e-7 - -0.86 1.7e-3 - - 5.6e-7 9.7e-3 - - - S265 LLNARVLS EIFSPML - - - - - - - - - - - Y452 VGKKLHEY NTQFQEK 0.12 - 6e-13 - - 0.035 -3e-7 -0.043 - 0.37 0.44 Y467 SREYDRLY EEYTRTS 0.27 - - - - 0.27 - - - - - Y556 LKKQAAEY REIDKRM -0.95 - 3.2e-12 - - 1.5e-5 -5.4e-13 -5.6e-6 - 0.55 - T576 DLIQLRKT RDQYLMW - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S36
S43
S83
T86
S154
S265
Y452
Y467
Y556
T576
Y580
Y607
S608
S628
S689
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation CCRCC S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation COAD S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation GBM S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation HNSCC S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation LSCC S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation LUAD S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation OV S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation PDAC S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation UCEC S36 S43 S83 T86 S154 S265 Y452 Y467 Y556 T576 Y580 Y607 S608 S628 S689 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S36
S43
S83
T86
S154
S265
Y452
Y467
Y556
T576
Y580
Y607
S608
S628
S689
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S36
S43
S83
T86
S154
S265
Y452
Y467
Y556
T576
Y580
Y607
S608
S628
S689
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.