Protein: ENSP00000428924
Gene: LYN

LinkedOmicsKB © 2022-2023 Zhang Lab

LYN:
LYN proto-oncogene, Src family tyrosine kinase

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S11IKSKGKDSLSDDGVD8489--44596645-189938689--2783716
S13SKGKDSLSDDGVDLK81301--94729710099-1086210899110101--96429518
T27KTQPVRNTERTIYVR18--------------71----
Y32RNTERTIYVRDPTSN352----------5544--2311--
T37TIYVRDPTSNKQQRP610016-1212----63191744--52--
S38IYVRDPTSNKQQRPV596------53-----547113553
S83GIHPDDLSFKKGEKM18------8-------------
S187IKHYKIRSLDNGGYY18----------44--------
Y194SLDNGGYYISPRITF5225------18---69641211--52359
S228RLEKACISPKPQKPW391----------15142219--156--
Showing 1 to 10 of 16 rows
1025
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Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S11IKSKGKDSLSDDGVD4.7e-18--8.7e-12--1.4e-6---8.2e-4
S13SKGKDSLSDDGVDLK1.6e-4-2.6e-152.3e-3-5.1e-4-2.8e-4-0.45-0.63-0.58
T27KTQPVRNTERTIYVR-----------
Y32RNTERTIYVRDPTSN1.1e-4--------1.1e-4-
T37TIYVRDPTSNKQQRP-----------
S38IYVRDPTSNKQQRPV-----------
S83GIHPDDLSFKKGEKM-----------
S187IKHYKIRSLDNGGYY-----------
Y194SLDNGGYYISPRITF-1.1e-6------1.1e-6----
S228RLEKACISPKPQKPW1.7e-4------1.7e-4---
Showing 1 to 10 of 16 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_IL6_JAK_STAT3_SIGNALINGS131.5e-37-2.2e-160.0184.5e-92.5e-71.4e-80.095-4.2e-41.6e-4
ESTIMATE: ImmuneScoreS132.1e-36-8.2e-110.172.2e-162e-81e-90.22-3.8e-42.1e-3
HALLMARK_ALLOGRAFT_REJECTIONS135.6e-35-2.2e-160.123.2e-101.7e-72.5e-80.12-1.3e-31.1e-3
PERT-PSP_ANTI_CD3S137.9e-34--1.6e-64.1e-50.0115.8e-10--1.2e-42.2e-16
xcell: Macrophage M1S136.3e-31-8.2e-100.314.8e-91.0e-61.3e-60.14-4.8e-75.4e-4
HALLMARK_INTERFERON_GAMMA_RESPONSES132.3e-30-1.5e-80.143.1e-91.4e-72.9e-100.22-4.2e-42.7e-3
HALLMARK_COMPLEMENTS132.7e-28-1e-70.192.3e-75.2e-76.2e-90.1-1.5e-31.7e-4
HALLMARK_INFLAMMATORY_RESPONSES135e-28-2.3e-80.083.3e-83.5e-54.2e-70.062-1.5e-38.3e-5
xcell: immune scoreS132.3e-25-7.3e-100.0498.6e-82.8e-75.5e-80.39-0.0120.042
KINASE-PSP_PKCA/PRKCAS136.4e-25--0.0150.0170.312.2e-163.5e-7-5.4e-43.0e-6
Showing 1 to 10 of 4128 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationCCRCCS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationCOADS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationGBMS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationHNSCCS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationLSCCS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationLUADS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationOVS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationPDACS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylationUCECS11S13T27Y32T37S38S83S187Y194S228Y265Y316Y473T502T504Y508proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PPP1CBS11-8.1e-10---6.0e-40.91-0.014-1.1e-7---6.1e-4-0.58
ENOPH1S13-2.2e-9--2.3e-4-0.4-0.029-0.28-0.031-0.14--5.4e-4-0.04
PPP1CBS13-1.5e-8--0.0020.83-0.93-0.32-2.1e-7-0.12--3.3e-4-0.082
MTMR2S11-2.2e-8---0.23-3.9e-3-0.056-5.8e-4---0.06-0.017
PTPN11S13-3.8e-7--0.23-0.098-0.15-0.085-3.5e-4-3.1e-3--0.86-0.097
NANPS13-9.4e-7--0.27-0.65-0.53-0.11-1.6e-3-0.047--9.9e-3-0.018
HDHD5S13-1.2e-6--6.8e-30.87-1.9e-3-0.025-7.4e-3-0.33--0.0230.93
PDXPS13-2.6e-6--0.2-0.048-5.5e-30.76-0.053-0.096--0.02-0.1
PTPRFS13-7.3e-6--0.5-0.15-0.012-2.2e-3-3.7e-3-0.9--0.33-0.31
PPP5CS13-8.5e-6--2.4e-4-0.13-0.570.220.24-0.054--8.4e-5-7.2e-4
Showing 1 to 10 of 3840 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.