DOCK2: dedicator of cytokinesis 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2rqr chain A
2yin chain A
2yin chain B
3a98 chain A
3a98 chain C
3b13 chain A
3b13 chain C
6tgb chain A
6tgb chain D
6tgc chain A
6tgc chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S515 RFMFRHRS SLESKDK 1 63 - - - - - - 63 - - - - - - - - - - - - - S585 KGATLSRS SSSVGGL 1 10 - - - - - - - - - - 5 5 - - - - - - - - S586 GATLSRSS SSVGGLS 1 9 - - - - - - - - - - - - - - - - - - 7 2 S587 ATLSRSSS SVGGLSV 9 788 - - 4 4 93 95 81 - 52 31 44 41 29 24 61 14 94 41 71 9 S588 TLSRSSSS VGGLSVS 1 10 - - - - - - - - - - 5 5 - - - - - - - - S838 LQKQKVQS MNEIVQS 2 18 - - - - - - - - - - 5 4 5 4 - - - - - - T1452 SRPVRRGT VDPENEF 1 9 - - - - - - 9 - - - - - - - - - - - - - S1592 KIHEKRVS DNLRPFH 10 1229 104 - 91 76 64 62 99 - 108 62 98 91 102 93 7 1 105 44 19 3 S1644 LRSYRQMS IISLASM 9 958 114 - 59 52 26 28 36 - 91 52 108 99 97 89 - - 58 25 20 4 S1647 YRQMSIIS LASMNSD 1 9 - - - - - - - - - - 5 4 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S515 RFMFRHRS SLESKDK - - - - - - - - - - - S585 KGATLSRS SSSVGGL - - - - - - - - - - - S586 GATLSRSS SSVGGLS - - - - - - - - - - - S587 ATLSRSSS SVGGLSV 0.36 - - -4.1e-4 - 6.1e-6 -2.9e-3 -0.51 -0.17 4.1e-10 - S588 TLSRSSSS VGGLSVS - - - - - - - - - - - S838 LQKQKVQS MNEIVQS - - - - - - - - - - - T1452 SRPVRRGT VDPENEF - - - - - - - - - - - S1592 KIHEKRVS DNLRPFH 8.9e-6 - 2.2e-20 0.23 - 5.8e-8 -2.6e-8 -3.6e-3 - 5.2e-4 - S1644 LRSYRQMS IISLASM 0.72 - 5.7e-13 -2.9e-7 - -0.11 -3.8e-3 0.18 - 0.052 - S1647 YRQMSIIS LASMNSD - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S515
S585
S586
S587
S588
S838
T1452
S1592
S1644
S1647
S1650
S1672
S1685
S1705
S1706
S1731
T1733
S1736
S1752
S1755
S1757
T1760
S1767
S1780
S1784
T1786
S1791
T1797
S1827
T1828
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation CCRCC S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation COAD S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation GBM S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation HNSCC S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation LSCC S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation LUAD S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation OV S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation PDAC S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation UCEC S515 S585 S586 S587 S588 S838 T1452 S1592 S1644 S1647 S1650 S1672 S1685 S1705 S1706 S1731 T1733 S1736 S1752 S1755 S1757 T1760 S1767 S1780 S1784 T1786 S1791 T1797 S1827 T1828 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S515
S585
S586
S587
S588
S838
T1452
S1592
S1644
S1647
S1650
S1672
S1685
S1705
S1706
S1731
T1733
S1736
S1752
S1755
S1757
T1760
S1767
S1780
S1784
T1786
S1791
T1797
S1827
T1828
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S515
S585
S586
S587
S588
S838
T1452
S1592
S1644
S1647
S1650
S1672
S1685
S1705
S1706
S1731
T1733
S1736
S1752
S1755
S1757
T1760
S1767
S1780
S1784
T1786
S1791
T1797
S1827
T1828
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.