HDAC2: histone deacetylase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3max chain A
3max chain B
3max chain C
4lxz chain A
4lxz chain B
4lxz chain C
4ly1 chain A
4ly1 chain B
4ly1 chain C
5iwg chain A
5iwg chain B
5iwg chain C
5ix0 chain A
5ix0 chain B
5ix0 chain C
6g3o chain A
6g3o chain B
6g3o chain C
6wbw chain A
6wbw chain B
6wbw chain C
6wbz chain A
6wbz chain B
6wbz chain C
6whn chain A
6whn chain B
6whn chain C
6who chain A
6who chain B
6who chain C
6whq chain A
6whq chain B
6whq chain C
6whz chain A
6whz chain B
6whz chain C
6wi3 chain A
6wi3 chain B
6wi3 chain C
6xdm chain A
6xdm chain B
6xdm chain C
6xeb chain A
6xeb chain B
6xeb chain C
6xec chain A
6xec chain B
6xec chain C
7js8 chain A
7js8 chain B
7js8 chain C
7kbg chain A
7kbg chain B
7kbg chain C
7kbh chain A
7kbh chain B
7kbh chain C
7ltg chain A
7ltg chain B
7ltg chain C
7ltk chain A
7ltk chain B
7ltk chain C
7ltl chain A
7ltl chain B
7ltl chain C
7mos chain A
7mos chain B
7mos chain C
7mot chain A
7mot chain B
7mot chain C
7mox chain A
7mox chain B
7mox chain C
7moy chain A
7moy chain B
7moy chain C
7moz chain A
7moz chain B
7moz chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S394 EDAVHEDS GDEDGED 10 1490 122 - 103 80 97 100 99 - 108 62 103 95 110 101 38 10 105 44 95 18 S407 EDPDKRIS IRASDKR 2 35 29 - 4 2 - - - - - - - - - - - - - - - - S411 KRISIRAS DKRIACD 6 159 37 - 29 18 - - - - - - 5 5 25 24 - - 5 2 - 9 S422 IACDEEFS DSEDEGE 10 1490 113 - 95 80 85 94 90 - 103 59 108 99 110 100 82 18 105 44 90 15 S424 CDEEFSDS EDEGEGG 10 490 17 - 103 80 17 19 9 - 19 9 15 12 16 16 13 3 22 11 91 18 S486 GTKSEQLS NP_____ 9 308 21 - 21 20 4 5 17 - - - 39 35 31 27 7 1 29 13 22 16
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S394 EDAVHEDS GDEDGED 1.9e-22 - -2e-7 4e-23 - 6.7e-7 1.9e-23 1.3e-16 -0.74 0.92 -0.9 S407 EDPDKRIS IRASDKR - - - - - - - - - - - S411 KRISIRAS DKRIACD 0.19 - 0.082 - - - - 0.9 - - - S422 IACDEEFS DSEDEGE 6e-35 - -4.7e-13 4.6e-16 - 4.1e-18 1.5e-23 3.5e-15 0.078 0.64 1.8e-7 S424 CDEEFSDS EDEGEGG 0.44 - -5.7e-4 - - - - - - -0.15 4.9e-10 S486 GTKSEQLS NP_____ -0.052 - 0.79 - - - -0.59 -0.045 - -1.3e-4 0.078
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S394
S407
S411
S422
S424
S486
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation CCRCC S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation COAD S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation GBM S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation HNSCC S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation LSCC S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation LUAD S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation OV S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation PDAC S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation UCEC S394 S407 S411 S422 S424 S486 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S394
S407
S411
S422
S424
S486
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S394
S407
S411
S422
S424
S486
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.