Protein: ENSP00000430432
Gene: HDAC2

LinkedOmicsKB © 2022-2023 Zhang Lab

HDAC2:
histone deacetylase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S394EDAVHEDSGDEDGED101490122-103809710099-10862103951101013810105449518
S407EDPDKRISIRASDKR23529-42----------------
S411KRISIRASDKRIACD615937-2918------552524--52-9
S422IACDEEFSDSEDEGE101490113-9580859490-10359108991101008218105449015
S424CDEEFSDSEDEGEGG1049017-1038017199-1991512161613322119118
S486GTKSEQLSNP_____930821-21204517---393531277129132216
Showing 1 to 6 of 6 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S394EDAVHEDSGDEDGED1.9e-22--2e-74e-23-6.7e-71.9e-231.3e-16-0.740.92-0.9
S407EDPDKRISIRASDKR-----------
S411KRISIRASDKRIACD0.19-0.082----0.9---
S422IACDEEFSDSEDEGE6e-35--4.7e-134.6e-16-4.1e-181.5e-233.5e-150.0780.641.8e-7
S424CDEEFSDSEDEGEGG0.44--5.7e-4-------0.154.9e-10
S486GTKSEQLSNP_____-0.052-0.79----0.59-0.045--1.3e-40.078
Showing 1 to 6 of 6 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CK2A1/CSNK2A1S3949.9e-515.4e-67.7e-41.1e-39.2e-75.3e-91.9e-81.1e-71.1e-33.4e-107.3e-7
KINASE-PSP_CK2A1/CSNK2A1S4222.1e-311.6e-50.0340.0140.0291.3e-81.1e-71.6e-50.198.8e-102.5e-3
HALLMARK_G2M_CHECKPOINTS4221e-211.0e-47.6e-30.190.135.7e-66.2e-61e-70.379.5e-32.5e-3
HALLMARK_G2M_CHECKPOINTS3945.7e-201.6e-30.380.251.2e-92.6e-52.6e-63.5e-70.24-0.74.3e-3
xcell: T cell CD4+ Th1S3942.3e-191.3e-40.375.3e-32.2e-80.0214.7e-54.3e-60.420.170.028
HALLMARK_E2F_TARGETSS3942.4e-182.7e-4-0.750.391.2e-94.2e-52.9e-72.9e-70.14-0.540.032
HALLMARK_MYC_TARGETS_V2S4221.9e-171.6e-30.0530.280.642.0e-41.5e-32.5e-61.4e-31.2e-30.027
HALLMARK_E2F_TARGETSS4221.5e-168.8e-40.140.550.312.7e-54.1e-53.4e-70.130.0110.024
HALLMARK_MITOTIC_SPINDLES3948.2e-150.0320.270.247.0e-60.0486.6e-32.7e-60.110.235.8e-4
HALLMARK_MITOTIC_SPINDLES4223.3e-141.2e-30.0140.820.0670.0023.2e-49.5e-7-0.291.2e-30.013
Showing 1 to 10 of 1548 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS394S407S411S422S424S486proteinRNASCNVmethylationCCRCCS394S407S411S422S424S486proteinRNASCNVmethylationCOADS394S407S411S422S424S486proteinRNASCNVmethylationGBMS394S407S411S422S424S486proteinRNASCNVmethylationHNSCCS394S407S411S422S424S486proteinRNASCNVmethylationLSCCS394S407S411S422S424S486proteinRNASCNVmethylationLUADS394S407S411S422S424S486proteinRNASCNVmethylationOVS394S407S411S422S424S486proteinRNASCNVmethylationPDACS394S407S411S422S424S486proteinRNASCNVmethylationUCECS394S407S411S422S424S486proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
TRRAPS3945.8e-334.9e-40.130.042.2e-162.2e-161.5e-72.2e-40.28-0.712.6e-6
VRK1S3947.5e-293.1e-32.1e-30.192.2e-162.6e-61.8e-71.2e-60.520.164.1e-3
BRD2S3943.2e-273.9e-54.5e-30.11.3e-81.6e-92.1e-90.0390.360.0632.5e-3
PRPF4BS3941.2e-265.0e-40.0281.4e-34.8e-95.7e-42.2e-163.8e-40.610.742.7e-3
TRIM28S3942.7e-230.0340.022.0e-42.2e-161.2e-47.4e-91.0e-40.52-0.0191.1e-3
BAZ1BS3946.8e-219.4e-40.460.0118.8e-71.1e-64.1e-55.3e-40.190.030.027
PRKDCS3943.1e-200.250.30.132.2e-164.8e-77.3e-62e-80.62-0.162.6e-3
CDK1S4221.6e-191.4e-30.0230.230.127.7e-54.2e-46.3e-100.554.1e-31.4e-3
CDK1S3945.7e-191.7e-40.0350.148.7e-82.7e-33.1e-43.8e-80.34-0.840.01
GTF2F1S3942.9e-184.2e-50.25-0.934.2e-70.372.6e-63.1e-30.42.9e-36.6e-7
Showing 1 to 10 of 3228 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
LHPPS422-8.4e-15-4.3e-4-0.094-0.11-0.037-0.01-2.7e-3-4.2e-5-0.099-6.9e-4-0.34
SSH3S394-4e-14-9.3e-50.98-0.75-5.8e-5-1.4e-4-1.2e-4-8.5e-30.63-0.006-1.7e-3
MTM1S394-6.5e-14-0.029-0.036-0.073-2.4e-6-0.049-2.5e-6-1.0e-61.5e-4-0.18-1.4e-4
DUSP22S422-7.1e-130.4-0.16-0.44-0.13-1.7e-3-5.2e-4-9.2e-9-0.23-0.016-1.0e-4
INPP4BS394-6.6e-11-2.6e-70.0560.42-3.1e-3-4.9e-4-2.0e-4-0.75-0.32-2.7e-3-2.0e-4
TNS2S422-9.1e-9-3.1e-3-0.31-0.042-0.1-0.18-0.22-3.1e-4-2.7e-30.93-0.15
DUSP3S422-1.2e-8-1.3e-4-0.1-0.052-0.37-8.8e-4-0.48-0.27-0.012-0.42-0.2
DUSP3S394-1.4e-8-0.069-0.015-0.56-1.1e-5-0.26-0.18-0.11-0.37-0.21-0.013
IMPA1S394-1.6e-81-0.54-0.014-1.1e-4-0.002-5.1e-3-0.17-0.12-0.081-0.67
LHPPS394-2.1e-8-0.35-0.56-0.086-0.019-0.1-0.019-2.2e-4-0.46-0.016-0.18
Showing 1 to 10 of 1440 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.