SPTBN2: spectrin beta, non-erythrocytic 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1wjm chain A
1wyq chain A
6anu chain a
6anu chain b
6anu chain c
6anu chain d
6anu chain e
6anu chain f
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S31 NRWDLPDS DWDNDSS 1 6 - - 3 3 - - - - - - - - - - - - - - - - S336 NDRQLANS LSGVQNQ 1 10 - - - - - - - - 7 3 - - - - - - - - - - S338 RQLANSLS GVQNQLQ 1 18 - - - - - - 18 - - - - - - - - - - - - - S449 SENQRLVS QDNFGLE 1 9 - - - - - - 9 - - - - - - - - - - - - - S772 DALRLVSS PELGHDE 9 542 72 - 27 26 - - 9 - 58 32 20 19 68 59 83 19 3 2 40 5 S959 AALTSALS IQNYHLE 2 17 - - - - - - 9 - 5 3 - - - - - - - - - - S1060 TMRRREES LGEARRL 2 50 31 - - - - - - - 13 6 - - - - - - - - - - S1073 RLQDFLRS LDDFQAW 6 217 6 - 8 8 - - - - 66 35 24 21 17 16 13 3 - - - - S1255 KIREKADS IERRHKK 10 648 22 - 15 14 24 21 89 - 57 32 35 31 42 40 77 15 65 29 29 11 S1753 IGQERVDS ANALANG 5 106 - - 4 4 - - - - 7 3 4 4 - - 47 12 - - 19 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S31 NRWDLPDS DWDNDSS - - - - - - - - - - - S336 NDRQLANS LSGVQNQ - - - - - - - - - - - S338 RQLANSLS GVQNQLQ - - - - - - - - - - - S449 SENQRLVS QDNFGLE - - - - - - - - - - - S772 DALRLVSS PELGHDE -0.9 - -9.9e-7 - - -2.1e-5 1.6e-5 3.2e-3 0.03 - - S959 AALTSALS IQNYHLE - - - - - - - - - - - S1060 TMRRREES LGEARRL - - - - - - - - - - - S1073 RLQDFLRS LDDFQAW -0.62 - - - - -1.5e-9 9.1e-8 - - - - S1255 KIREKADS IERRHKK 2.4e-38 - - 3.5e-8 - -0.54 3.1e-19 4.4e-21 7.4e-5 0.011 8.6e-6 S1753 IGQERVDS ANALANG 0.69 - - - - - - - 0.69 - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S31
S336
S338
S449
S772
S959
S1060
S1073
S1255
S1753
Y1801
S1940
S1941
S1964
S1965
S2038
S2050
S2162
S2171
S2199
S2254
S2332
T2354
S2359
S2384
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation CCRCC S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation COAD S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation GBM S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation HNSCC S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation LSCC S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation LUAD S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation OV S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation PDAC S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation UCEC S31 S336 S338 S449 S772 S959 S1060 S1073 S1255 S1753 Y1801 S1940 S1941 S1964 S1965 S2038 S2050 S2162 S2171 S2199 S2254 S2332 T2354 S2359 S2384 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S31
S336
S338
S449
S772
S959
S1060
S1073
S1255
S1753
Y1801
S1940
S1941
S1964
S1965
S2038
S2050
S2162
S2171
S2199
S2254
S2332
T2354
S2359
S2384
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S31
S336
S338
S449
S772
S959
S1060
S1073
S1255
S1753
Y1801
S1940
S1941
S1964
S1965
S2038
S2050
S2162
S2171
S2199
S2254
S2332
T2354
S2359
S2384
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.