CHEK1: checkpoint kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ia8 chain A
1nvq chain A
1nvr chain A
1nvs chain A
1zlt chain A
1zys chain A
2ayp chain A
2br1 chain A
2brb chain A
2brg chain A
2brh chain A
2brm chain A
2brn chain A
2bro chain A
2c3j chain A
2c3k chain A
2c3l chain A
2cgu chain A
2cgv chain A
2cgw chain A
2cgx chain A
2e9n chain A
2e9o chain A
2e9p chain A
2e9u chain A
2e9v chain A
2e9v chain B
2gdo chain A
2ghg chain A
2hog chain A
2hxl chain A
2hxq chain A
2hy0 chain A
2qhm chain A
2qhn chain A
2r0u chain A
2wmq chain A
2wmr chain A
2wms chain A
2wmt chain A
2wmu chain A
2wmv chain A
2wmw chain A
2wmx chain A
2x8d chain A
2x8e chain A
2x8i chain A
2xey chain A
2xez chain A
2xf0 chain A
2ydi chain A
2ydj chain A
2ydj chain B
2ydk chain A
2yer chain A
2yex chain A
2ym3 chain A
2ym4 chain A
2ym5 chain A
2ym6 chain A
2ym7 chain A
2ym8 chain A
2ywp chain A
3f9n chain A
3jvr chain A
3jvs chain A
3nlb chain A
3ot3 chain A
3ot8 chain A
3pa3 chain A
3pa4 chain A
3pa5 chain A
3tkh chain A
3tki chain A
3u9n chain A
4fsm chain A
4fsn chain A
4fsq chain A
4fsr chain A
4fst chain A
4fsu chain A
4fsw chain A
4fsy chain A
4fsz chain A
4ft0 chain A
4ft3 chain A
4ft5 chain A
4ft7 chain A
4ft9 chain A
4fta chain A
4ftc chain A
4fti chain A
4ftj chain A
4ftk chain A
4ftl chain A
4ftm chain A
4ftn chain A
4fto chain A
4ftq chain A
4ftr chain A
4ftt chain A
4ftu chain A
4gh2 chain A
4hyh chain A
4hyi chain A
4jik chain A
4qye chain A
4qyf chain A
4qyg chain A
4qyg chain B
4qyh chain A
4qyh chain B
4rvk chain A
4rvl chain A
4rvm chain A
5dls chain A
5f4n chain A
5oop chain A
5oor chain A
5oot chain A
5op2 chain A
5op4 chain A
5op5 chain A
5op7 chain A
5opb chain A
5opr chain A
5ops chain A
5opu chain A
5opv chain A
5oq5 chain A
5oq6 chain A
5oq7 chain A
5oq7 chain B
5oq8 chain A
5wi2 chain A
5wi2 chain B
6fc8 chain A
6fcf chain A
6fck chain A
7akm chain A
7akm chain B
7ako chain A
7ako chain B
7bjd chain A
7bje chain A
7bjh chain A
7bjj chain A
7bjm chain A
7bjo chain A
7bjr chain A
7bjx chain A
7bjx chain B
7bk1 chain A
7bk2 chain A
7bk3 chain A
7bkn chain A
7bko chain A
7mck chain A
7suf chain A
7sug chain A
7suh chain A
7sui chain A
7suj chain A
7suj chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S280 AKRPRVTS GGVSESP 10 421 32 - 12 11 9 9 18 - 28 16 34 32 49 46 28 7 43 15 16 16 S286 TSGGVSES PSGFSKH 6 80 26 - 4 4 - - 9 - 5 4 - - - - 8 1 - - 19 - S296 GFSKHIQS NLDFSPV 7 256 9 - - - 30 23 - - 18 9 29 28 36 32 26 5 - - 9 2 S301 IQSNLDFS PVNSASS 5 156 40 - - - - - 9 - 34 20 15 13 - - 21 4 - - - - S317 ENVKYSSS QPEPRTG 6 149 14 - - - 12 6 - - 28 14 14 12 - - 31 9 - - - 9 S331 GLSLWDTS PSYIDKL 10 312 36 - 12 12 23 13 8 - 22 15 64 59 9 8 16 4 4 1 6 -
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S280 AKRPRVTS GGVSESP 1.6e-14 - - - - 3.7e-3 2.7e-9 1.9e-3 - 6.8e-4 - S286 TSGGVSES PSGFSKH - - - - - - - - - - - S296 GFSKHIQS NLDFSPV 6.3e-9 - - -0.074 - - 7.2e-10 1.3e-8 - - - S301 IQSNLDFS PVNSASS 2.3e-3 - - - - 2.3e-3 - - - - - S317 ENVKYSSS QPEPRTG 9.2e-5 - - - - 9.2e-5 - - - - - S331 GLSLWDTS PSYIDKL 7.7e-14 - - -0.79 - 7.5e-5 2.3e-20 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S280
S286
S296
S301
S317
S331
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation CCRCC S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation COAD S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation GBM S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation HNSCC S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation LSCC S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation LUAD S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation OV S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation PDAC S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation UCEC S280 S286 S296 S301 S317 S331 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S280
S286
S296
S301
S317
S331
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S280
S286
S296
S301
S317
S331
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.