Protein: ENSP00000437550
Gene: LATS1

LinkedOmicsKB © 2022-2023 Zhang Lab

LATS1:
large tumor suppressor kinase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T17YRQMRPKTFPASNYT974381-2622--72-8549646085772782610447
S37MLQEIRESLRNLSKP218------------45-----9
S84ALQEIRNSLLPFANE724014-1616----634438393771127--
S139EAAIEFISKMSYQDP241--------------269--6-
S177QSVNRKQSWKGSKES5167------45---1081312--51208-
S181RKQSWKGSKESLVPQ93088---403245-161110813122053916285
S218VGRPLSGSGISAFVQ199-------------------
T246PPQVRSVTPPPPPRG101213122-6449728099-925488806959751857229518
T255PPPPRGQTPPPRGTT832933-44810----19176256671694164
T261QTPPPRGTTPPPPSW515081-98------55108----222
Showing 1 to 10 of 25 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T17YRQMRPKTFPASNYT-3.6e-18--0.96---2.8e-9-1.2e-8-3.6e-8--0.026-
S37MLQEIRESLRNLSKP-----------
S84ALQEIRNSLLPFANE-5.5e-5------1.1e-3-0.015---
S139EAAIEFISKMSYQDP-----------
S177QSVNRKQSWKGSKES-0.12---------0.12-
S181RKQSWKGSKESLVPQ0.14--2.8e-7------2.2e-3-
S218VGRPLSGSGISAFVQ-----------
T246PPQVRSVTPPPPPRG3.7e-9--11.3e-9-1.7e-80.023-1.3e-3-0.220.671.7e-8
T255PPPPRGQTPPPRGTT2e-7------2.9e-51.5e-3--
T261QTPPPRGTTPPPPSW-----------
Showing 1 to 10 of 25 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationCCRCCT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationCOADT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationGBMT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationHNSCCT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationLSCCT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationLUADT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationOVT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationPDACT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylationUCECT17S37S84S139S177S181S218T246T255T261T262S267S278S289S464S569S613T616S635S872S876Y1026S1049S1104S1111proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.