Protein: ENSP00000440542
Gene: CHD4

LinkedOmicsKB © 2022-2023 Zhang Lab

CHD4:
chromodomain helicase DNA binding protein 4

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S85LCRQLGDSSGEGPEF41149-----62---53------305
S86CRQLGDSSGEGPEFV51059-----62---53108----8-
S103EEEVALRSDSEGSDY8432105-88--80-593310988--68288-
S105EVALRSDSEGSDYTP8650105-9068--80-59335497--68287816
S108LRSDSEGSDYTPGKK8583105-9068--8-59331039444--726-
Y110SDSEGSDYTPGKKKK2179-44----------------
S1648VEKVEEKSAIDLTPI967848-3939--81-16114441988926737147315
T1653EKSAIDLTPIVVEDK91245104-9572--99-108621039510093611488389518
T1679VMLQNGETPKDLNDE974996-2827--71-5028989058521332088918
S1831EVECLAESHQHLSKE261------37-----1212------
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S85LCRQLGDSSGEGPEF-----------
S86CRQLGDSSGEGPEFV-----------
S103EEEVALRSDSEGSDY-0.043-----2.5e-3---0.87-
S105EVALRSDSEGSDYTP-5.9e-3--2.7e-7---2.2e-3---0.840.012
S108LRSDSEGSDYTPGKK0.75--4.3e-6---2.2e-36.1e-22----
Y110SDSEGSDYTPGKKKK-----------
S1648VEKVEEKSAIDLTPI3.5e-20-1.7e-5---7.7e-171.1e-15--0.170.19
T1653EKSAIDLTPIVVEDK1.6e-17--0.045--7.9e-74e-228.5e-173.4e-4-0.0150.65
T1679VMLQNGETPKDLNDE1.8e-12--0.065--2.5e-37.9e-286.6e-4--0.81
S1831EVECLAESHQHLSKE-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationCCRCCS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationCOADS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationGBMS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationHNSCCS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationLSCCS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationLUADS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationOVS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationPDACS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylationUCECS85S86S103S105S108Y110S1648T1653T1679S1831proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.