PLCB3: phospholipase C beta 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4gnk chain B
4gnk chain D
4gnk chain E
4qj3 chain B
4qj4 chain B
4qj5 chain B
7sq2 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S270 LYPPLRPS QARLLIE 6 134 - - 3 3 - - 45 - - - 13 12 4 4 35 8 5 2 - - S474 NKKRHRPS AGGPDSA 9 436 39 - - - 96 99 53 - 6 3 4 4 41 37 13 3 13 5 17 3 S480 PSAGGPDS AGRKRPL 9 516 7 - - - 94 93 28 - 36 18 34 32 40 36 13 2 36 14 20 13 S492 RPLEQSNS ALSESSA 6 172 6 - - - - - 44 - - - 9 9 4 4 - - 17 8 53 18 S495 EQSNSALS ESSAATE 1 18 - - - - - - 18 - - - - - - - - - - - - - S497 SNSALSES SAATEPS 2 15 - - - - - - 9 - - - - - - - - - 4 2 - - S498 NSALSESS AATEPSS 1 9 - - - - - - 9 - - - - - - - - - - - - - T501 LSESSAAT EPSSPQL 3 23 - - - - - - - - - - - - 5 4 - - 3 2 - 9 S504 SSAATEPS SPQLGSP 6 78 - - 4 4 - - 9 - - - 5 5 9 8 - - 3 2 26 3 S505 SAATEPSS PQLGSPS 7 238 - - 5 4 - - 54 - 6 4 10 9 5 4 - - 44 15 67 11
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S270 LYPPLRPS QARLLIE - - - - - - - - - - - S474 NKKRHRPS AGGPDSA 7.6e-11 - - 2.7e-12 - - - 0.027 - - - S480 PSAGGPDS AGRKRPL 8.9e-4 - - 1.9e-6 - 0.71 -0.95 0.38 - 0.62 0.094 S492 RPLEQSNS ALSESSA -0.078 - - - - - - - - - -0.078 S495 EQSNSALS ESSAATE - - - - - - - - - - - S497 SNSALSES SAATEPS - - - - - - - - - - - S498 NSALSESS AATEPSS - - - - - - - - - - - T501 LSESSAAT EPSSPQL - - - - - - - - - - - S504 SSAATEPS SPQLGSP - - - - - - - - - - - S505 SAATEPSS PQLGSPS 0.79 - - - - - - - - 0.071 -0.15
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S270
S474
S480
S492
S495
S497
S498
T501
S504
S505
S510
S512
S513
S515
S537
S604
S632
S911
S916
T925
S926
T930
S931
S933
S934
S1105
S1107
S1209
S1225
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation CCRCC S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation COAD S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation GBM S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation HNSCC S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation LSCC S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation LUAD S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation OV S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation PDAC S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation UCEC S270 S474 S480 S492 S495 S497 S498 T501 S504 S505 S510 S512 S513 S515 S537 S604 S632 S911 S916 T925 S926 T930 S931 S933 S934 S1105 S1107 S1209 S1225 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S270
S474
S480
S492
S495
S497
S498
T501
S504
S505
S510
S512
S513
S515
S537
S604
S632
S911
S916
T925
S926
T930
S931
S933
S934
S1105
S1107
S1209
S1225
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S270
S474
S480
S492
S495
S497
S498
T501
S504
S505
S510
S512
S513
S515
S537
S604
S632
S911
S916
T925
S926
T930
S931
S933
S934
S1105
S1107
S1209
S1225
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.