FRS2: fibroblast growth factor receptor substrate 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1xr0 chain B
2mfq chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T132 TELEVPRT PRTPTTP 5 87 8 - - - - - 25 - 13 6 10 8 - - 12 5 - - - - T135 EVPRTPRT PTTPGFA 9 428 53 - 8 - - - 90 - 25 14 5 4 18 17 41 11 37 18 71 16 T137 PRTPRTPT TPGFAAQ 4 52 - - - - - - 9 - 7 2 - - - - - - 7 4 19 4 T138 RTPRTPTT PGFAAQN 4 67 8 - - - - - 18 - - - - - - - 8 1 - - 18 14 S155 NGYPRYPS FGDASSH 4 139 17 - - - - - 62 - 13 6 - - - - 35 6 - - - - S164 GDASSHPS SRHPSVG 1 8 - - - - - - - - - - - - - - 6 2 - - - - S169 HPSSRHPS VGSARLP 7 634 67 - - - 32 30 71 - 102 59 69 63 - - 78 16 - - 34 13 S172 SRHPSVGS ARLPSVG 1 8 - - - - - - - - - - - - - - 6 2 - - - - S177 VGSARLPS VGEESTH 5 125 - - - - - - 80 - 7 2 5 5 9 8 7 2 - - - - T210 QEERKNRT SVHVPLE 1 9 - - - - 4 5 - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T132 TELEVPRT PRTPTTP - - - - - - - - - - - T135 EVPRTPRT PTTPGFA -2.7e-5 - - - - -0.087 - - -0.077 -0.043 -3.9e-3 T137 PRTPRTPT TPGFAAQ - - - - - - - - - - - T138 RTPRTPTT PGFAAQN - - - - - - - - - - - S155 NGYPRYPS FGDASSH - - - - - - - - - - - S164 GDASSHPS SRHPSVG - - - - - - - - - - - S169 HPSSRHPS VGSARLP 1.2e-13 - - 0.068 - 1.9e-17 9.4e-14 - 0.45 - -0.052 S172 SRHPSVGS ARLPSVG - - - - - - - - - - - S177 VGSARLPS VGEESTH - - - - - - - - - - - T210 QEERKNRT SVHVPLE - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T132
T135
T137
T138
S155
S164
S169
S172
S177
T210
S211
S221
S225
S226
T227
S234
T288
Y290
S292
Y306
S316
S327
T328
T330
S339
Y349
S354
S365
T376
S378
S403
S428
S445
S447
T455
T458
T463
T465
S503
T504
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation CCRCC T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation COAD T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation GBM T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation HNSCC T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation LSCC T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation LUAD T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation OV T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation PDAC T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation UCEC T132 T135 T137 T138 S155 S164 S169 S172 S177 T210 S211 S221 S225 S226 T227 S234 T288 Y290 S292 Y306 S316 S327 T328 T330 S339 Y349 S354 S365 T376 S378 S403 S428 S445 S447 T455 T458 T463 T465 S503 T504 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T132
T135
T137
T138
S155
S164
S169
S172
S177
T210
S211
S221
S225
S226
T227
S234
T288
Y290
S292
Y306
S316
S327
T328
T330
S339
Y349
S354
S365
T376
S378
S403
S428
S445
S447
T455
T458
T463
T465
S503
T504
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T132
T135
T137
T138
S155
S164
S169
S172
S177
T210
S211
S221
S225
S226
T227
S234
T288
Y290
S292
Y306
S316
S327
T328
T330
S339
Y349
S354
S365
T376
S378
S403
S428
S445
S447
T455
T458
T463
T465
S503
T504
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.