Protein: ENSP00000450607
Gene: TIMELESS

LinkedOmicsKB © 2022-2023 Zhang Lab

TIMELESS:
timeless circadian regulator

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S308LHNLRNYSSDLGKQP126------------------224
S431TDRKEAASWARRMHL16------------------6-
S685ELQVVQVSEKEFNFL19------9-------------
S962ILPNGAESLKDFCQE3110------18---1010------5814
S1087WRIPAKLSPTQLRRA829915---9954-47302524--347832311
S1121KVPGEQGSDEEHCKE101039114-2828928799-108627867585213358215318
S1149KKKAGLASPEEEDAV10830113-2422313235-88478980393541102299518
S1173KKRQLLDSDEEQEED101340105-9472727190-10862108991069714298408418
Showing 1 to 8 of 8 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S308LHNLRNYSSDLGKQP-----------
S431TDRKEAASWARRMHL-----------
S685ELQVVQVSEKEFNFL-----------
S962ILPNGAESLKDFCQE0.007---------0.007
S1087WRIPAKLSPTQLRRA4.1e-8----2.3e-43.8e-9----0.94
S1121KVPGEQGSDEEHCKE1e-33-6.7e-38e-16-1.5e-156.3e-240.22-0.830.08
S1149KKKAGLASPEEEDAV2.9e-51-0.0931.7e-12-1.2e-91.4e-273e-133e-7-0.086
S1173KKRQLLDSDEEQEED2.8e-64-7.8e-82.7e-14-9.4e-173.7e-332.6e-29--0.0290.014
Showing 1 to 8 of 8 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationCCRCCS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationCOADS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationGBMS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationHNSCCS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationLSCCS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationLUADS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationOVS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationPDACS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylationUCECS308S431S685S962S1087S1121S1149S1173proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.