NUMB: NUMB endocytic adaptor protein
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5njj chain A
5njj chain B
5njj chain C
5njj chain D
5njk chain A
5njk chain B
5njk chain C
5njk chain D
5njk chain E
5njk chain F
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S91 VKAVLWVS ADGLRVV 1 9 - - - - - - - - - - 5 4 - - - - - - - - S194 TTFTREGS FRVTTAT 10 1167 122 - 95 72 15 12 44 - 108 62 108 99 110 101 15 3 105 44 37 15 T235 SSVAPGNT APSPSSP 4 44 18 - - - 1 7 8 - - - 5 5 - - - - - - - - S238 APGNTAPS PSSPTSP 7 152 - - - - 1 7 53 - - - 5 5 3 4 4 1 13 7 47 2 S240 GNTAPSPS SPTSPTS 6 226 - - - - 8 10 45 - 6 3 - - - - 31 5 29 10 70 9 S241 NTAPSPSS PTSPTSD 7 186 - - - - 13 14 63 - 5 3 - - 4 5 7 1 12 3 40 16 T243 APSPSSPT SPTSDAT 10 517 40 - 53 35 8 9 17 - 46 25 29 29 42 36 7 1 71 30 35 4 S244 PSPSSPTS PTSDATT 10 423 8 - 8 8 16 19 17 - 7 3 61 56 88 81 7 2 4 1 28 9 T246 PSSPTSPT SDATTSL 2 25 - - - - 6 12 - - - - - - - - - - 5 2 - - S247 SSPTSPTS DATTSLE 4 43 - - - - 2 7 16 - 5 3 5 5 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S91 VKAVLWVS ADGLRVV - - - - - - - - - - - S194 TTFTREGS FRVTTAT 0.84 - -4.0e-5 - - 7.3e-10 -8.8e-4 -4.7e-3 - 4.4e-4 0.28 T235 SSVAPGNT APSPSSP - - - - - - - - - - - S238 APGNTAPS PSSPTSP - - - - - - - - - - - S240 GNTAPSPS SPTSPTS -0.3 - - - - - - - - -0.3 - S241 NTAPSPSS PTSPTSD 0.023 - - - - - - - - - 0.023 T243 APSPSSPT SPTSDAT -2.1e-3 - 0.036 - - -0.4 -1.3e-5 -7.0e-5 - 0.84 - S244 PSPSSPTS PTSDATT -1.2e-20 - - - - - -5e-11 -3.8e-11 - - - T246 PSSPTSPT SDATTSL - - - - - - - - - - - S247 SSPTSPTS DATTSLE - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S91
S194
T235
S238
S240
S241
T243
S244
T246
S247
T250
T251
S252
S295
S326
S361
T363
S420
S421
S425
T436
S438
T561
Y565
S568
S573
S599
S634
T636
S640
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation CCRCC S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation COAD S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation GBM S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation HNSCC S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation LSCC S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation LUAD S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation OV S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation PDAC S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation UCEC S91 S194 T235 S238 S240 S241 T243 S244 T246 S247 T250 T251 S252 S295 S326 S361 T363 S420 S421 S425 T436 S438 T561 Y565 S568 S573 S599 S634 T636 S640 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S91
S194
T235
S238
S240
S241
T243
S244
T246
S247
T250
T251
S252
S295
S326
S361
T363
S420
S421
S425
T436
S438
T561
Y565
S568
S573
S599
S634
T636
S640
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S91
S194
T235
S238
S240
S241
T243
S244
T246
S247
T250
T251
S252
S295
S326
S361
T363
S420
S421
S425
T436
S438
T561
Y565
S568
S573
S599
S634
T636
S640
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.