Protein: ENSP00000452414
Gene: PTPN21

LinkedOmicsKB © 2022-2023 Zhang Lab

PTPN21:
protein tyrosine phosphatase non-receptor type 21

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S492RPAALVYSQPEIREH1076080-382581044-412354507768741735188018
S504REHAQLPSPAAAHCP127------27-------------
S538RPVVGAVSVPELTNA1081140-3128142161-593171721009221360276416
T543AVSVPELTNAQLQAQ941021-4128369-44284441686072--62
S554LQAQDYPSPNIMRTQ217----------55--7-----
Y569VYRPPPPYPPPRPAN19--------54----------
S577PPPRPANSTPDLSRH101107105-7756365397-472610899101937282356716
T578PPRPANSTPDLSRHL3295--8160------1097065------
S589SRHLYISSSNPDLIT6699-44----5310944134----
S590RHLYISSSNPDLITR1097225-2917707390-613679725647701685339518
Showing 1 to 10 of 28 rows
102550
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S492RPAALVYSQPEIREH-6.4e-18--0.066---0.24-1.4e-17-2.2e-21-0.780.19-4.9e-3
S504REHAQLPSPAAAHCP-----------
S538RPVVGAVSVPELTNA-2.8e-13--0.55---4.1e-3-1.7e-11-1.4e-19-0.031-0.42
T543AVSVPELTNAQLQAQ-7.9e-33--0.031---1.7e-7-2.2e-17-1.2e-15---
S554LQAQDYPSPNIMRTQ-----------
Y569VYRPPPPYPPPRPAN-----------
S577PPPRPANSTPDLSRH-4.5e-40--1.1e-13-2.3e-10--0.94-4.3e-34-2.3e-28-3.9e-4-0.12
T578PPRPANSTPDLSRHL-7.5e-14--2.3e-3-----5.3e-14---
S589SRHLYISSSNPDLIT-----------
S590RHLYISSSNPDLITR-3.7e-19--3.1e-6-0.004--0.11-3e-25-2.7e-16-0.0121.4e-7-0.74
Showing 1 to 10 of 28 rows
102550
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationCCRCCS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationCOADS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationGBMS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationHNSCCS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationLSCCS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationLUADS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationOVS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationPDACS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylationUCECS492S504S538T543S554Y569S577T578S589S590S602S616S637S658S660S670S673S702S710S711S774S775S795S797S804S820S861S863proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.