Protein: ENSP00000457991
Gene: PHLPP2

LinkedOmicsKB © 2022-2023 Zhang Lab

PHLPP2:
PH domain and leucine rich repeat protein phosphatase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S6__MKRNGSRNCLNRR118----711--------------
S1119PRPERRCSLHPTPTS275------63---------84--
S1143ATFSSNQSDNGLDSD340--77--18-----------62
S1149QSDNGLDSDDDQPVE625459-54--90---99108----4614
S1182RGRDLENSPPLIESS18--------------62----
S1189SPPLIESSPTLCSEE126--------------224----
S1210FGIRRQNSVNSGMLL841324---374364---2523131212465284716
S1213RRQNSVNSGMLLPMS199-------------------
S1229DRMELQKSPSTSCLY15----------------41--
S1231MELQKSPSTSCLYGK631825---172790---2424----21106416
Showing 1 to 10 of 13 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S6__MKRNGSRNCLNRR-----------
S1119PRPERRCSLHPTPTS-----------
S1143ATFSSNQSDNGLDSD-----------
S1149QSDNGLDSDDDQPVE-2.1e-3----------2.1e-3
S1182RGRDLENSPPLIESS-----------
S1189SPPLIESSPTLCSEE-----------
S1210FGIRRQNSVNSGMLL-8.8e-3---6.2e-9---0.025--1.3e-3-0.69
S1213RRQNSVNSGMLLPMS-----------
S1229DRMELQKSPSTSCLY-----------
S1231MELQKSPSTSCLYGK8.2e-3-----1.7e-4--0.12-0.47
Showing 1 to 10 of 13 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationCCRCCS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationCOADS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationGBMS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationHNSCCS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationLSCCS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationLUADS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationOVS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationPDACS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylationUCECS6S1119S1143S1149S1182S1189S1210S1213S1229S1231T1232S1241S1244proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.