SRGAP2: SLIT-ROBO Rho GTPase activating protein 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2dl8 chain A
4rtt chain A
4rtt chain B
4rug chain A
4rug chain B
5i6j chain A
5i6r chain A
5i7d chain A
5i7d chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S487 ESQRTDCS LARRSST 6 153 17 - - - 13 14 10 - - - 35 33 - - 15 2 9 5 - - S500 STVRKQDS SQAIPLV 3 40 - - - - - - 27 - 5 3 - - - - - - 3 2 - - S501 TVRKQDSS QAIPLVV 2 27 - - - - - - 9 - - - 10 8 - - - - - - - - S691 ELEGPVYS RGGSMED 3 63 - - - - - - 37 - - - 5 5 - - 14 2 - - - - S695 PVYSRGGS MEDYCDS 1 18 - - - - - - 18 - - - - - - - - - - - - - S702 SMEDYCDS PHGETTS 3 52 - - - - - - 34 - - - 5 5 - - - - - - 5 3 T707 CDSPHGET TSVEDST 1 9 - - - - - - - - - - - - - - - - - - - 9 S709 SPHGETTS VEDSTQD 2 56 - - - - - - 51 - - - - - - - - - 3 2 - - S713 ETTSVEDS TQDVTAE 2 15 8 - - - - - - - - - 3 4 - - - - - - - - T714 TTSVEDST QDVTAEH 3 44 8 - 4 4 - - - - - - 15 13 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S487 ESQRTDCS LARRSST 0.3 - - - - - 0.3 - - - - S500 STVRKQDS SQAIPLV - - - - - - - - - - - S501 TVRKQDSS QAIPLVV - - - - - - - - - - - S691 ELEGPVYS RGGSMED - - - - - - - - - - - S695 PVYSRGGS MEDYCDS - - - - - - - - - - - S702 SMEDYCDS PHGETTS - - - - - - - - - - - T707 CDSPHGET TSVEDST - - - - - - - - - - - S709 SPHGETTS VEDSTQD - - - - - - - - - - - S713 ETTSVEDS TQDVTAE - - - - - - - - - - - T714 TTSVEDST QDVTAEH - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S487
S500
S501
S691
S695
S702
T707
S709
S713
T714
T718
T723
S724
S754
T787
S795
S796
S799
S845
S854
S860
S877
S884
S900
S903
S905
S916
S930
S965
T969
S983
T989
S990
S993
S994
S1013
T1014
S1053
S1058
T1060
S1061
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation CCRCC S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation COAD S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation GBM S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation HNSCC S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation LSCC S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation LUAD S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation OV S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation PDAC S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation UCEC S487 S500 S501 S691 S695 S702 S709 S713 T714 T718 T723 S724 S754 T787 S795 S796 S799 S845 S854 S860 S877 S884 S900 S903 S905 S916 S930 S965 T969 S983 T989 S990 S993 S994 S1013 T1014 S1053 S1058 T1060 S1061 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S487
S500
S501
S691
S695
S702
T707
S709
S713
T714
T718
T723
S724
S754
T787
S795
S796
S799
S845
S854
S860
S877
S884
S900
S903
S905
S916
S930
S965
T969
S983
T989
S990
S993
S994
S1013
T1014
S1053
S1058
T1060
S1061
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S487
S500
S501
S691
S695
S702
T707
S709
S713
T714
T718
T723
S724
S754
T787
S795
S796
S799
S845
S854
S860
S877
S884
S900
S903
S905
S916
S930
S965
T969
S983
T989
S990
S993
S994
S1013
T1014
S1053
S1058
T1060
S1061
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.