OTUD7B: OTU deubiquitinase 7B
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5lru chain A
5lrv chain A
5lrw chain A
5lrw chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S55 HAGNLPPS FSEGSGG 1 9 9 - - - - - - - - - - - - - - - - - - - S60 PPSFSEGS GGSRTPE 3 24 - - 4 4 - - 9 - - - - - - - - - - - 5 2 T65 EGSGGSRT PEKGFSD 4 65 - - 7 7 3 6 17 - - - - - - - 19 6 - - - - S100 KRLSRGIS HASSSIV 10 652 90 - 4 4 57 59 89 - 35 21 30 26 68 60 61 14 5 2 25 2 S103 SRGISHAS SSIVSLA 3 58 23 - - - - - 18 - - - - - - - - - - - 6 11 S104 RGISHASS SIVSLAR 4 65 23 - - - - - - - 10 7 - - 5 4 12 4 - - - - S105 GISHASSS IVSLARS 6 122 9 - - - - - 18 - 10 7 - - 5 4 43 8 - - 7 11 S245 QTQQNKES GLVYTED 1 17 - - - - - - 17 - - - - - - - - - - - - - S417 RLASVILS LEVKLHL 1 9 - - - - - - - - 6 3 - - - - - - - - - - S449 APLAQPES PTASAGD 10 1476 122 - 99 78 80 81 98 - 107 62 108 99 110 101 62 13 105 44 89 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S55 HAGNLPPS FSEGSGG - - - - - - - - - - - S60 PPSFSEGS GGSRTPE - - - - - - - - - - - T65 EGSGGSRT PEKGFSD - - - - - - - - - - - S100 KRLSRGIS HASSSIV -0.043 - - -2.7e-3 - 0.58 -0.2 -0.5 -0.9 - - S103 SRGISHAS SSIVSLA - - - - - - - - - - - S104 RGISHASS SIVSLAR - - - - - - - - - - - S105 GISHASSS IVSLARS - - - - - - - - - - - S245 QTQQNKES GLVYTED - - - - - - - - - - - S417 RLASVILS LEVKLHL - - - - - - - - - - - S449 APLAQPES PTASAGD -3.7e-11 - -0.068 -4.6e-5 - -1.2e-3 -0.35 -0.25 -2.8e-3 -4.4e-6 0.94
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S55
S60
T65
S100
S103
S104
S105
S245
S417
S449
T451
S453
S460
T461
S464
S467
S471
S474
S475
S476
T477
S478
S542
S543
T547
S745
S748
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation CCRCC S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation COAD S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation GBM S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation HNSCC S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation LSCC S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation LUAD S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation OV S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation PDAC S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation UCEC S55 S60 T65 S100 S103 S104 S105 S245 S417 S449 T451 S453 S460 T461 S464 S467 S471 S474 S475 S476 T477 S478 S542 S543 T547 S745 S748 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S55
S60
T65
S100
S103
S104
S105
S245
S417
S449
T451
S453
S460
T461
S464
S467
S471
S474
S475
S476
T477
S478
S542
S543
T547
S745
S748
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S55
S60
T65
S100
S103
S104
S105
S245
S417
S449
T451
S453
S460
T461
S464
S467
S471
S474
S475
S476
T477
S478
S542
S543
T547
S745
S748
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.