Protein: ENSP00000463999
Gene: AURKB

LinkedOmicsKB © 2022-2023 Zhang Lab

AURKB:
aurora kinase B

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T35VLRKEPVTPSALVLM113------------------112
Y151FYDRRRIYLILEYAP110--------73----------
Y156RIYLILEYAPRGELY110--------73----------
S227GWSVHAPSLRRKTMC2178-------54----------
Showing 1 to 4 of 4 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T35VLRKEPVTPSALVLM-----------
Y151FYDRRRIYLILEYAP-----------
Y156RIYLILEYAPRGELY-----------
S227GWSVHAPSLRRKTMC-----------
Showing 1 to 4 of 4 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_PAK1T350.034---------0.034
PATH-NP_TIE2_PATHWAYT350.037---------0.037
HALLMARK_PROTEIN_SECRETIONT350.052---------0.052
xcell: Cancer associated fibroblastT350.065---------0.066
cibersort: Myeloid dendritic cell activatedT350.08---------0.08
xcell: EosinophilT350.093---------0.093
xcell: stroma scoreT350.1---------0.1
SBS7b (UVR)T350.12---------0.12
HALLMARK_UV_RESPONSE_DNT350.12---------0.12
xcell: Granulocyte-monocyte progenitorT350.14---------0.14
Showing 1 to 10 of 1032 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT35Y151Y156S227proteinRNASCNVmethylationCCRCCT35Y151Y156S227proteinRNASCNVmethylationCOADT35Y151Y156S227proteinRNASCNVmethylationGBMT35Y151Y156S227proteinRNASCNVmethylationHNSCCT35Y151Y156S227proteinRNASCNVmethylationLSCCT35Y151Y156S227proteinRNASCNVmethylationLUADT35Y151Y156S227proteinRNASCNVmethylationOVT35Y151Y156S227proteinRNASCNVmethylationPDACT35Y151Y156S227proteinRNASCNVmethylationUCECT35Y151Y156S227proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PRKCAT350.031---------0.031
TGFBR1T350.034---------0.034
ABL1T350.037---------0.037
GRK3T350.037---------0.037
MTORT350.04---------0.04
STK11T350.052---------0.052
DAPK2T350.071---------0.071
MYLKT350.076---------0.076
MAP3K8T350.081---------0.082
PRKG1T350.087---------0.087
Showing 1 to 10 of 2152 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
INPPL1T35-8.1e-3----------8.1e-3
LPIN3T35-0.012----------0.012
FIG4T35-0.028----------0.028
ILKAPT35-0.037----------0.037
PTPRET35-0.048----------0.048
CTDNEP1T35-0.11----------0.11
PPP5CT35-0.11----------0.11
HDHD3T35-0.12----------0.12
PPTC7T35-0.13----------0.13
PGAM5T35-0.16----------0.16
Showing 1 to 10 of 960 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.