Protein: ENSP00000466214
Gene: PDCD5

LinkedOmicsKB © 2022-2023 Zhang Lab

PDCD5:
programmed cell death 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S42REAEMRNSILAQVLD73029-1514------343190808142122
S51LAQVLDQSARARLSN845422-66443610-11759536860----3015
S57QSARARLSNLALVKP114--77----------------
S119NRRKVMDSDEDDDY_101545122-103809710099-1086210899106978319105449518
Y125DSDEDDDY_______985779-88666272--4223797154481249238189
Showing 1 to 5 of 5 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S42REAEMRNSILAQVLD-0.072-----0.81-5.3e-3---
S51LAQVLDQSARARLSN-8.2e-7-6.8e-3----4.2e-10-0.07---6.5e-6
S57QSARARLSNLALVKP-----------
S119NRRKVMDSDEDDDY_0.16-1.4e-6-0.082-6.3e-32.8e-150.075-0.009-2.5e-11-0.028
Y125DSDEDDDY_______0.7-1.9e-150.74-0.20.35-3.1e-8--3.5e-9-
Showing 1 to 5 of 5 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CK2A1/CSNK2A1S1198.2e-329.8e-41.3e-54.4e-50.0132.1e-36.9e-54.8e-30.122.2e-161.2e-3
KINASE-PSP_CK2A1/CSNK2A1Y1252.8e-80.0910.760.35-2.8e-44.6e-30.620.922.4e-70.13
HALLMARK_HYPOXIAS515.6e-60.921.2e-3-0.0210.340.0260.01--0.53
HALLMARK_COAGULATIONS421.8e-5-0.28---2.7e-40.019--0.13
KINASE-PSP_GSK3BS1191.9e-5---1.2e-32.1e-5-0.2--0.030.24
PROGENy: TNFaS428.5e-5-0.43---7.2e-50.082--0.18
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONS421.3e-4--0.5---2.8e-35.8e-4--0.055
ESTIMATE: StromalScoreS421.9e-4--0.089---1.2e-42.1e-3--0.024
HALLMARK_SPERMATOGENESISY1251.9e-4-0.710.290.077-0.0680.210.420.430.0360.05
PROGENy: NFkBS422.3e-4-0.89---3.1e-50.14--0.12
Showing 1 to 10 of 1290 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS42S51S57S119Y125proteinRNASCNVmethylationCCRCCS42S51S57S119Y125proteinRNASCNVmethylationCOADS42S51S57S119Y125proteinRNASCNVmethylationGBMS42S51S57S119Y125proteinRNASCNVmethylationHNSCCS42S51S57S119Y125proteinRNASCNVmethylationLSCCS42S51S57S119Y125proteinRNASCNVmethylationLUADS42S51S57S119Y125proteinRNASCNVmethylationOVS42S51S57S119Y125proteinRNASCNVmethylationPDACS42S51S57S119Y125proteinRNASCNVmethylationUCECS42S51S57S119Y125proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
INPP4BS119-1.7e-7-5.9e-3-0.016-0.390.71-0.16-5.1e-3-0.980.63-1.1e-6-0.025
SSH3S119-7.1e-5-0.0883.3e-5-0.083-0.2-6.2e-3-5.9e-3-0.480.56-2.1e-4-7.3e-3
GAKS119-3.8e-4-0.28-0.48-0.24-0.74-0.88-0.035-0.0840.89-0.14-8.9e-3
PTPN9Y125-7.1e-40.85-9.6e-5-9.6e-3--0.045-0.60.34-0.3-0.110.74
G6PCS119-7.4e-4--7.4e-4--------
ILKAPS42-7.8e-4-0.86----5.6e-3-0.025---0.059
ENOPH1S119-7.9e-4-0.493.1e-3-0.008-0.075-0.21-0.87-0.38-0.94-1.0e-6-0.23
PTPN11S119-8.1e-4-0.047-0.770.38-0.12-0.65-0.28-0.0280.37-3.8e-6-0.87
ACP3S42-8.7e-4--0.84----1.6e-3-0.021---0.32
PTPN3S42-9.7e-4--0.7----5.8e-3-7.3e-3---0.44
Showing 1 to 10 of 1200 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.