Protein: ENSP00000468004
Gene: HDAC5

LinkedOmicsKB © 2022-2023 Zhang Lab

HDAC5:
histone deacetylase 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S24LEILPRTSLHSIPVT199-------------------
S53MGGGGGGSPSPVELR727338-2621------2928363314394239
S55GGGGGSPSPVELRGA5111--88--9---992220----233
S220CWGAHHASLDQSSPP343--44--27---44--------
S229DQSSPPQSGPPGTPP326--44--9---54--------
T234PQSGPPGTPPSYKLP19------9-------------
S498RPLSRTQSSPLPQSP8313----141381-137151310815237165316
S499PLSRTQSSPLPQSPQ101039113-9976272654-96557368978920574322411
S504QSSPLPQSPQALQQL214--33--------44------
S611VKDEEGESGAEEGPD9116278-9068--82-108621049589814711100408918
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S24LEILPRTSLHSIPVT-----------
S53MGGGGGGSPSPVELR-0.025-0.11----6.4e-5-0.13---
S55GGGGGSPSPVELRGA-8.8e-3-------8.8e-3---
S220CWGAHHASLDQSSPP-----------
S229DQSSPPQSGPPGTPP-----------
T234PQSGPPGTPPSYKLP-----------
S498RPLSRTQSSPLPQSP-1.4e-7---------1.7e-3-1.6e-5
S499PLSRTQSSPLPQSPQ-4.7e-37--0.017-5.6e-3--1.4e-8-5.1e-19-2e-17--0.001-0.033
S504QSSPLPQSPQALQQL-----------
S611VKDEEGESGAEEGPD-2.9e-32--0.39---1.9e-14-2.9e-17-1.6e-16-6.4e-50.37-2.9e-3
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationCCRCCS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationCOADS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationGBMS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationHNSCCS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationLSCCS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationLUADS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationOVS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationPDACS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylationUCECS24S53S55S220S229T234S498S499S504S611S661S662S671S1108proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.