PAK4: p21 (RAC1) activated kinase 4
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2bva chain A
2bva chain B
2cdz chain A
2j0i chain A
2ov2 chain I
2ov2 chain J
2ov2 chain K
2ov2 chain L
2ov2 chain M
2ov2 chain N
2ov2 chain O
2ov2 chain P
2q0n chain A
2x4z chain A
4app chain A
4fie chain A
4fie chain B
4fif chain A
4fif chain B
4fif chain C
4fif chain D
4fig chain A
4fig chain B
4fih chain A
4fii chain A
4fii chain B
4fij chain A
4jdh chain A
4jdi chain A
4jdj chain A
4jdk chain A
4l67 chain A
4l67 chain B
4njd chain A
4o0v chain A
4o0x chain A
4o0y chain A
4xbr chain A
4xbu chain A
5bms chain A
5i0b chain A
5upk chain A
5upk chain B
5upl chain A
5ved chain A
5vee chain A
5vef chain A
5xva chain A
5xvf chain A
5xvg chain A
5zjw chain A
6wlx chain A
6wly chain A
7cmb chain A
7cp3 chain A
7cp4 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S41 GLPRQWQS LIEESAR 7 500 - - 25 16 - - 72 - 40 25 65 61 50 44 - - 16 7 61 18 S74 PKTIVRGS KGAKDGA 4 226 - - - - - - - - - - 25 22 33 28 - - 33 15 55 15 S93 LDEFENMS VTRSNSL 2 23 - - - - - - - - - - - - 8 8 - - - - 7 - S97 ENMSVTRS NSLRRDS 4 87 - - 4 2 - - - - 18 10 5 5 23 20 - - - - - - S99 MSVTRSNS LRRDSPP 5 163 - - 4 2 - - 36 - - - 5 5 14 12 - - - - 72 13 S104 SNSLRRDS PPPPARA 7 1132 - - 103 80 - - 99 - 108 62 108 99 110 101 - - 105 44 95 18 S142 RGRFAGHS EAGGGSG 7 92 14 - - - 6 11 18 - - - 5 5 - - 15 3 6 2 5 2 S148 HSEAGGGS GDRRRAG 10 1410 121 - 56 47 78 74 98 - 108 62 108 99 110 101 76 16 105 44 89 18 S167 PKSSREGS GGPQESS 7 283 7 - - - - - 72 - 6 4 10 9 - - 29 5 47 19 57 18 S173 GSGGPQES SRDKRPL 4 138 - - 42 31 - - - - - - - - - - 6 2 19 8 23 7
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S41 GLPRQWQS LIEESAR 0.32 - 0.61 - - 0.55 0.79 7.1e-6 - - -2.8e-4 S74 PKTIVRGS KGAKDGA -1.3e-10 - - - - - -5.4e-3 -5.7e-5 - -0.055 -3.8e-5 S93 LDEFENMS VTRSNSL - - - - - - - - - - - S97 ENMSVTRS NSLRRDS -0.12 - - - - - - -0.12 - - - S99 MSVTRSNS LRRDSPP -0.19 - - - - - - - - - -0.19 S104 SNSLRRDS PPPPARA -2.3e-6 - -1.1e-24 - - 1.5e-3 2.8e-9 1.9e-3 - 2e-8 0.051 S142 RGRFAGHS EAGGGSG - - - - - - - - - - - S148 HSEAGGGS GDRRRAG -0.21 - 3.5e-3 4.9e-3 - 5.2e-3 -0.068 -3.6e-22 0.067 -4.1e-4 -0.75 S167 PKSSREGS GGPQESS 3.7e-3 - - - - - - - - 9.9e-6 -0.75 S173 GSGGPQES SRDKRPL -0.068 - -0.068 - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S41
S74
S93
S97
S99
S104
S142
S148
S167
S173
S181
T187
T207
S217
S244
S245
S247
S258
S267
T277
S291
S445
S474
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation CCRCC S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation COAD S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation GBM S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation HNSCC S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation LSCC S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation LUAD S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation OV S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation PDAC S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation UCEC S41 S74 S93 S97 S99 S104 S142 S148 S167 S173 S181 T187 T207 S217 S244 S245 S247 S258 S267 T277 S291 S445 S474 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S41
S74
S93
S97
S99
S104
S142
S148
S167
S173
S181
T187
T207
S217
S244
S245
S247
S258
S267
T277
S291
S445
S474
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S41
S74
S93
S97
S99
S104
S142
S148
S167
S173
S181
T187
T207
S217
S244
S245
S247
S258
S267
T277
S291
S445
S474
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.