SETD1B: SET domain containing 1B, histone lysine methyltransferase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3uvo chain B
4es0 chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T198 LLVTGRYT PQTLPVG 4 30 - - - - 4 5 - - 6 3 - - 4 4 - - - - 4 - S211 VGELDAVS PIVNETL 10 1291 96 - 99 77 89 90 90 - 108 62 83 77 105 97 23 4 105 42 41 3 T244 GSGSSSVT PNSGGTP 4 82 18 - - - - - 18 - - - - - - - 7 1 - - 27 11 T273 PNSYGQGT PLTPRLG 1 9 - - - - - - - - - - 5 4 - - - - - - - - T276 YGQGTPLT PRLGTPF 8 382 31 - 4 4 - - 45 - - - 25 24 44 40 49 10 5 2 81 18 T295 SYSSRQPT PSYLFSQ 5 40 - - - - - - 8 - - - - - 4 3 6 1 3 2 11 2 T381 DSATFAHT PPPAQAT 10 1464 104 - 103 80 75 86 90 - 108 62 108 99 110 101 61 15 105 44 95 18 T388 TPPPAQAT PAPGFKS 1 9 - - 5 4 - - - - - - - - - - - - - - - - S395 TPAPGFKS AFSPYQT 1 16 - - - - - - - - - - - - - - - - - - 14 2 S398 PGFKSAFS PYQTPVA 4 129 8 - - - - - 18 - - - - - - - 42 6 - - 50 5
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T198 LLVTGRYT PQTLPVG - - - - - - - - - - - S211 VGELDAVS PIVNETL -0.83 - -9.6e-6 0.83 - -0.25 0.56 0.082 - 3.7e-4 - T244 GSGSSSVT PNSGGTP 1.9e-4 - - - - - - - - - 1.9e-4 T273 PNSYGQGT PLTPRLG - - - - - - - - - - - T276 YGQGTPLT PRLGTPF 0.31 - - - - - 0.13 -0.12 0.83 - 0.066 T295 SYSSRQPT PSYLFSQ - - - - - - - - - - - T381 DSATFAHT PPPAQAT 3.3e-4 - -0.17 0.74 - 0.14 9.6e-3 1.9e-10 0.01 0.35 -5.7e-3 T388 TPPPAQAT PAPGFKS - - - - - - - - - - - S395 TPAPGFKS AFSPYQT - - - - - - - - - - - S398 PGFKSAFS PYQTPVA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T198
S211
T244
T273
T276
T295
T381
T388
S395
S398
Y400
T402
T450
T469
S473
S479
T558
S634
S635
S642
S935
S984
T985
S986
S994
T1005
S1031
S1102
S1137
T1142
S1144
S1148
S1283
S1298
T1425
T1433
T1435
S1437
S1464
T1558
S1659
S1663
S1770
T1771
S1807
T1809
S1811
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation CCRCC T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation COAD T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation GBM T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation HNSCC T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation LSCC T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation LUAD T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation OV T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation PDAC T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation UCEC T198 S211 T244 T273 T276 T295 T381 T388 S395 S398 Y400 T402 T450 T469 S473 S479 T558 S634 S635 S642 S935 S984 T985 S986 S994 T1005 S1031 S1102 S1137 T1142 S1144 S1148 S1283 S1298 T1425 T1433 T1435 S1437 S1464 T1558 S1659 S1663 S1770 T1771 S1807 T1809 S1811 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T198
S211
T244
T273
T276
T295
T381
T388
S395
S398
Y400
T402
T450
T469
S473
S479
T558
S634
S635
S642
S935
S984
T985
S986
S994
T1005
S1031
S1102
S1137
T1142
S1144
S1148
S1283
S1298
T1425
T1433
T1435
S1437
S1464
T1558
S1659
S1663
S1770
T1771
S1807
T1809
S1811
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T198
S211
T244
T273
T276
T295
T381
T388
S395
S398
Y400
T402
T450
T469
S473
S479
T558
S634
S635
S642
S935
S984
T985
S986
S994
T1005
S1031
S1102
S1137
T1142
S1144
S1148
S1283
S1298
T1425
T1433
T1435
S1437
S1464
T1558
S1659
S1663
S1770
T1771
S1807
T1809
S1811
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.