RPAP2:
RNA polymerase II associated protein 2

Lollipop plot

Phosphosites location and occurrence

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Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S178KEEQSGHSGEEVQLC19--------------72----
S300QKVNTQSSSNSTLPE19------------------72
S315RLKASENSESEYSRS5186------54---3532262571--6-
S352NQVSRSVSSSVQVCP72028-------531010447153226015
S414LDEDDIISDPDSHFP984853-6956--71-10862888250443196327314
S429AWRESQNSLDESLPF583--42--26-1510--54----512
S448TAIKPLPSYENLKKE3459---------54------189
Showing 1 to 7 of 7 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S178KEEQSGHSGEEVQLC-----------
S300QKVNTQSSSNSTLPE-----------
S315RLKASENSESEYSRS-0.33------0.61-0.38---
S352NQVSRSVSSSVQVCP0.21--------0.069-0.97
S414LDEDDIISDPDSHFP0.28-3.0e-4---0.150.065-0.46--0.4-
S429AWRESQNSLDESLPF-----------
S448TAIKPLPSYENLKKE-----------
Showing 1 to 7 of 7 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PATH-NP_EGFR1_PATHWAYS3152.0e-6---0.16-8.2e-54.1e-3---
PATH-NP_EGFR1_PATHWAYS4142.4e-50.28-0.82-0.0720.68-0.920.037-9.2e-43.7e-4
KINASE-PSP_PKCA/PRKCAS4149.4e-50.13--0.0960.220.0290.0690.6-0.990.035
PERT-PSP_SII_ANGIOTENSIN_2S4144.8e-4---0.2---0.132.1e-30.26
PERT-PSP_PHORBOL_ESTERS4145.7e-4---0.270.430.650.120.450.020.034
KINASE-PSP_AMPKA1/PRKAA1S4141.2e-3---0.39----0.0120.024
KINASE-PSP_Chk1/CHEK1S3521.4e-3-----0.1--0.120.02
KINASE-PSP_PKCA/PRKCAS3151.8e-3----0.53-1.9e-33.3e-3---
KINASE-PSP_mTOR/MTORS3151.8e-3---1.8e-3------
PERT-PSP_EGFS4140.0020.52-0.64-0.23-0.86-0.640.0920.0268.7e-30.042
Showing 1 to 10 of 1806 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS178S300S315S352S414S429S448proteinRNASCNVmethylationCCRCCS178S300S315S352S414S429S448proteinRNASCNVmethylationCOADS178S300S315S352S414S429S448proteinRNASCNVmethylationGBMS178S300S315S352S414S429S448proteinRNASCNVmethylationHNSCCS178S300S315S352S414S429S448proteinRNASCNVmethylationLSCCS178S300S315S352S414S429S448proteinRNASCNVmethylationLUADS178S300S315S352S414S429S448proteinRNASCNVmethylationOVS178S300S315S352S414S429S448proteinRNASCNVmethylationPDACS178S300S315S352S414S429S448proteinRNASCNVmethylationUCECS178S300S315S352S414S429S448proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.