Protein: ENSP00000478061
Gene: MARCKS

LinkedOmicsKB © 2022-2023 Zhang Lab

MARCKS:
myristoylated alanine rich protein kinase C substrate

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S26PGEAAVASSPSKANG5529-874510-------72----
S27GEAAVASSPSKANGQ1098588-1312929699-503164593936831984346818
S29AAVASSPSKANGQEN950075---798218-63433816187138184513
S46VKVNGDASPAAAESG101553122-103809710099-10862108991101018319105449518
S52ASPAAAESGAKEELQ854065-1515--73-261869644035--65281611
S63EELQANGSAPAADKE101477113-10380908999-108621089910697711491408918
S77EEPAAAGSGAASPSA10850104-5744212490-492688818780267331869
S81AAGSGAASPSAAEKG10127349-8664636299-9857108999889558105447118
S83GSGAASPSAAEKGEP380----30339-------62----
S101AAPEAGASPVEKEAP101521122-103809710099-10862103941101018319100428414
Showing 1 to 10 of 29 rows
102550
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S26PGEAAVASSPSKANG-----------
S27GEAAVASSPSKANGQ-0.37---9.7e-4-0.0261.5e-14-0.0240.02-1.2e-13-0.1
S29AAVASSPSKANGQEN-1.2e-25---4.8e-6---1.3e-8---2e-8-3.8e-7
S46VKVNGDASPAAAESG0.49-1.8e-16-9.8e-8-8.8e-107.9e-25-5.0e-6-0.51-1.9e-15-0.036
S52ASPAAAESGAKEELQ1.9e-9----4.1e-91.6e-100.12--0.065-
S63EELQANGSAPAADKE-1.4e-13-0.015-1.6e-15-6.5e-9-3.5e-5-1.4e-30-0.97-1.7e-7-0.79
S77EEPAAAGSGAASPSA-1.7e-3-0.16-2.1e-4-0.541.4e-4-1e-9--2.4e-4-
S81AAGSGAASPSAAEKG-3.9e-36--0.034-1.5e-3--1.2e-3-2.9e-5-3.4e-23--2.2e-18-0.067
S83GSGAASPSAAEKGEP-1.3e-8---1.3e-8-------
S101AAPEAGASPVEKEAP-3e-56--1.1e-5-1.2e-6--2e-8-1.4e-18-4.7e-23-3.2e-3-7.3e-6-2.1e-4
Showing 1 to 10 of 29 rows
102550
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationCCRCCS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationCOADS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationGBMS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationHNSCCS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationLSCCS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationLUADS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationOVS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationPDACS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylationUCECS26S27S29S46S52S63S77S81S83S101S118T120S128S131S132T133S134S135T143S145S147T150S159S163S167S170S211S252S262proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.