ACACA: acetyl-CoA carboxylase alpha
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2yl2 chain A
2yl2 chain B
3coj chain H
3coj chain I
3coj chain J
3coj chain K
3coj chain L
3coj chain M
3coj chain N
3coj chain O
4asi chain A
4asi chain B
4asi chain C
4asi chain D
4asi chain E
4asi chain F
6g2d chain B
6g2d chain C
6g2d chain D
6g2d chain F
6g2h chain A
6g2h chain B
6g2h chain C
6g2h chain D
6g2h chain E
6g2h chain F
6g2i chain A
6g2i chain B
6g2i chain C
6g2i chain D
6g2i chain E
6g2i chain F
6g2i chain G
6g2i chain J
6g2i chain Q
6g2i chain R
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S23 HSRFIIGS VSEDNSE 7 201 - - 4 4 9 9 45 - 34 21 - - 4 4 - - 3 2 53 9 S25 RFIIGSVS EDNSEDE 10 824 47 - 15 15 67 67 81 - 43 28 75 69 59 57 5 3 85 37 55 16 S29 GSVSEDNS EDEISNL 10 1524 122 - 103 80 97 100 99 - 108 62 108 99 110 101 73 16 96 38 94 18 S34 DNSEDEIS NLVKLDL 5 73 16 - - - - - 9 - - - 15 15 4 5 - - - - 7 2 S48 LLEEKEGS LSPASVG 1 9 - - - - - - - - - - - - 5 4 - - - - - - S50 EEKEGSLS PASVGSD 4 57 8 - 3 3 - - 9 - - - - - 17 17 - - - - - - S60 SVGSDTLS DLGISSL 2 16 - - 4 4 - - 8 - - - - - - - - - - - - - S77 GLALHIRS SMSGLHL 1 9 - - - - - - 9 - - - - - - - - - - - - - S78 LALHIRSS MSGLHLV 4 56 7 - - - - - - - 5 3 - - 9 8 19 5 - - - - S80 LHIRSSMS GLHLVKQ 10 1553 122 - 103 80 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S23 HSRFIIGS VSEDNSE -4.5e-7 - - - - -4.5e-7 - - - - - S25 RFIIGSVS EDNSEDE -2.9e-14 - - -8.1e-13 - -6.5e-6 -9.8e-11 0.28 - 4.1e-3 -9.1e-6 S29 GSVSEDNS EDEISNL 4.5e-3 - -1.1e-3 1.2e-5 - -2.7e-7 4.5e-4 3.3e-5 -0.27 3.9e-5 0.16 S34 DNSEDEIS NLVKLDL - - - - - - - - - - - S48 LLEEKEGS LSPASVG - - - - - - - - - - - S50 EEKEGSLS PASVGSD - - - - - - - - - - - S60 SVGSDTLS DLGISSL - - - - - - - - - - - S77 GLALHIRS SMSGLHL - - - - - - - - - - - S78 LALHIRSS MSGLHLV - - - - - - - - - - - S80 LHIRSSMS GLHLVKQ 7.8e-60 - 0.001 1.2e-16 - 3e-9 7.4e-10 7.3e-22 0.25 6.8e-13 5.7e-6
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S23
S25
S29
S34
S48
S50
S60
S77
S78
S80
S96
S488
T610
S756
S835
S841
S1201
S1203
S1204
Y1209
T1212
S1216
S1218
S1257
S1259
S1263
T1265
T1272
S1273
S2343
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation CCRCC S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation COAD S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation GBM S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation HNSCC S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation LSCC S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation LUAD S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation OV S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation PDAC S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation UCEC S23 S25 S29 S34 S48 S50 S60 S77 S78 S80 S96 S488 T610 S756 S835 S841 S1201 S1203 S1204 Y1209 T1212 S1216 S1218 S1257 S1259 S1263 T1265 T1272 S1273 S2343 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S23
S25
S29
S34
S48
S50
S60
S77
S78
S80
S96
S488
T610
S756
S835
S841
S1201
S1203
S1204
Y1209
T1212
S1216
S1218
S1257
S1259
S1263
T1265
T1272
S1273
S2343
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S23
S25
S29
S34
S48
S50
S60
S77
S78
S80
S96
S488
T610
S756
S835
S841
S1201
S1203
S1204
Y1209
T1212
S1216
S1218
S1257
S1259
S1263
T1265
T1272
S1273
S2343
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.