RPS6KA5: ribosomal protein S6 kinase A5
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1vzo chain A
3kn5 chain A
3kn5 chain B
3kn6 chain A
3kn6 chain B
7up4 chain A
7up4 chain B
7up5 chain A
7up5 chain B
7up7 chain A
7up7 chain B
7up8 chain A
7up8 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T38 ELRTANLT GHAEKVG 4 189 - - - - - - 27 - - - 44 39 27 24 - - - - 17 11 S212 DETERAYS FCGTIEY 7 715 - - 24 22 - - 81 - 50 25 103 94 101 92 - - 20 8 77 18 T216 RAYSFCGT IEYMAPD 3 53 - - 9 8 - - - - - - 10 9 9 8 - - - - - - Y219 SFCGTIEY MAPDIVR 2 72 - - - - - - - - 10 5 30 27 - - - - - - - - T353 SNFAEEFT EMDPTYS 2 55 - - - - - - - - - - 5 5 24 21 - - - - - - S367 SPAALPQS SEKLFQG 1 8 - - - - - - - - - - - - 4 4 - - - - - - S376 EKLFQGYS FVAPSIL 7 697 - - 96 73 - - 71 - 106 62 14 15 70 64 - - 59 22 34 11 S381 GYSFVAPS ILFKRNA 1 5 - - - - - - - - - - - - - - - - 3 2 - - S417 RSAMMKDS PFYQHYD 1 9 - - - - - - 9 - - - - - - - - - - - - - Y420 MMKDSPFY QHYDLDL 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T38 ELRTANLT GHAEKVG -8e-10 - - - - - -2.2e-6 -7.5e-5 - - - S212 DETERAYS FCGTIEY -7.2e-11 - -0.17 - - -8.6e-5 -0.068 -2.1e-9 - - -0.14 T216 RAYSFCGT IEYMAPD - - - - - - - - - - - Y219 SFCGTIEY MAPDIVR -0.058 - - - - - -0.058 - - - - T353 SNFAEEFT EMDPTYS -0.026 - - - - - - -0.026 - - - S367 SPAALPQS SEKLFQG - - - - - - - - - - - S376 EKLFQGYS FVAPSIL -8.8e-10 - 0.032 - - -4.2e-19 - -8.7e-10 - 0.13 -0.021 S381 GYSFVAPS ILFKRNA - - - - - - - - - - - S417 RSAMMKDS PFYQHYD - - - - - - - - - - - Y420 MMKDSPFY QHYDLDL - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T38
S212
T216
Y219
T353
S367
S376
S381
S417
Y420
Y423
S436
S448
S517
S628
S633
S694
S695
T700
S750
S752
S758
S759
S762
S783
S788
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation CCRCC T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation COAD T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation GBM T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation HNSCC T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation LSCC T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation LUAD T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation OV T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation PDAC T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation UCEC T38 S212 T216 Y219 T353 S367 S376 S381 S417 Y420 Y423 S436 S448 S517 S628 S633 S694 S695 T700 S750 S752 S758 S759 S762 S783 S788 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T38
S212
T216
Y219
T353
S367
S376
S381
S417
Y420
Y423
S436
S448
S517
S628
S633
S694
S695
T700
S750
S752
S758
S759
S762
S783
S788
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T38
S212
T216
Y219
T353
S367
S376
S381
S417
Y420
Y423
S436
S448
S517
S628
S633
S694
S695
T700
S750
S752
S758
S759
S762
S783
S788
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.