BRAF: B-Raf proto-oncogene, serine/threonine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1uwh chain A
1uwh chain B
1uwj chain A
1uwj chain B
2fb8 chain A
2fb8 chain B
2l05 chain A
3c4c chain A
3c4c chain B
3d4q chain A
3d4q chain B
3idp chain A
3idp chain B
3ii5 chain A
3ii5 chain B
3ny5 chain A
3ny5 chain B
3ny5 chain C
3ny5 chain D
3og7 chain A
3og7 chain B
3ppj chain A
3ppj chain B
3ppk chain A
3ppk chain B
3prf chain A
3prf chain B
3pri chain A
3pri chain B
3psb chain A
3psb chain B
3psd chain A
3psd chain B
3q4c chain A
3q4c chain B
3q96 chain A
3q96 chain B
3skc chain A
3skc chain B
3tv4 chain A
3tv4 chain B
3tv6 chain A
3tv6 chain B
4cqe chain A
4cqe chain B
4dbn chain A
4dbn chain B
4e26 chain A
4e26 chain B
4e4x chain A
4e4x chain B
4ehe chain A
4ehe chain B
4ehg chain A
4ehg chain B
4fc0 chain A
4fc0 chain B
4fk3 chain A
4fk3 chain B
4g9c chain A
4g9c chain B
4g9r chain A
4g9r chain B
4h58 chain A
4h58 chain B
4h58 chain C
4jvg chain A
4jvg chain B
4jvg chain C
4jvg chain D
4ksp chain A
4ksp chain B
4ksq chain A
4ksq chain B
4mbj chain A
4mbj chain B
4mne chain B
4mne chain C
4mne chain F
4mne chain G
4mnf chain A
4mnf chain B
4pp7 chain A
4pp7 chain B
4r5y chain A
4r5y chain B
4rzv chain A
4rzv chain B
4rzw chain A
4rzw chain B
4wo5 chain A
4wo5 chain B
4xv1 chain A
4xv1 chain B
4xv2 chain A
4xv2 chain B
4xv3 chain A
4xv3 chain B
4xv9 chain A
4yht chain A
4yht chain B
5c9c chain A
5c9c chain B
5csw chain A
5csw chain B
5csx chain A
5ct7 chain A
5ct7 chain B
5fd2 chain A
5fd2 chain B
5hi2 chain A
5hid chain A
5hid chain B
5hie chain A
5hie chain B
5hie chain C
5hie chain D
5ita chain A
5ita chain B
5j17 chain A
5j18 chain A
5j2r chain A
5jrq chain A
5jrq chain B
5jsm chain A
5jsm chain B
5jsm chain C
5jsm chain D
5jt2 chain A
5jt2 chain B
5jt2 chain C
5jt2 chain D
5val chain A
5val chain B
5vam chain A
5vam chain B
5vr3 chain A
5vyk chain A
5vyk chain C
6b8u chain A
6b8u chain B
6cad chain A
6cad chain B
6n0p chain A
6n0p chain B
6n0q chain A
6n0q chain B
6nsq chain A
6nsq chain B
6nyb chain A
6p3d chain A
6p7g chain A
6p7g chain B
6p7g chain C
6p7g chain D
6pp9 chain A
6q0j chain A
6q0j chain B
6q0k chain A
6q0k chain B
6q0t chain A
6q0t chain B
6u2g chain B
6u2h chain C
6u2h chain D
6uan chain B
6uan chain C
6uuo chain A
6uuo chain B
6v2u chain A
6v2u chain B
6v2w chain A
6v34 chain A
6v34 chain B
6xag chain C
6xag chain D
6xfp chain A
6xlo chain A
6xlo chain B
7k0v chain A
7k0v chain B
7k0v chain C
7k0v chain D
7m0t chain A
7m0u chain A
7m0v chain A
7m0w chain A
7m0x chain A
7m0y chain A
7m0z chain A
7mfd chain A
7mfe chain A
7mff chain A
7mff chain B
7p3v chain A
7p3v chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S76 GGEHNPPS IYLEAYE 1 9 - - - - - - - - - - - - 5 4 - - - - - - S147 NPTDVARS NPKSPQK 2 45 - - - - - - - - - - 15 15 - - - - - - 10 5 S151 VARSNPKS PQKPIVR 7 1098 - - 95 72 - - 99 - 98 54 108 99 110 101 - - 105 44 95 18 T313 SLAETALT SGSSPSA 5 74 - - 8 8 - - 7 - 5 2 20 19 - - - - 4 1 - - S316 ETALTSGS SPSAPAS 1 10 - - - - - - - - 6 4 - - - - - - - - - - S319 LTSGSSPS APASDSI 4 67 - - - - - - 37 - 5 4 - - - - - - 9 3 7 2 S323 SSPSAPAS DSIGPQI 1 9 - - - - - - - - - - - - 5 4 - - - - - - S325 PSAPASDS IGPQILT 1 8 - - - - - - - - 4 4 - - - - - - - - - - T332 SIGPQILT SPSPSKS 2 35 - - - - - - - - - - 5 5 13 12 - - - - - - S333 IGPQILTS PSPSKSI 6 298 - - 12 4 - - 89 - 6 3 39 36 22 21 - - 47 19 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S76 GGEHNPPS IYLEAYE - - - - - - - - - - - S147 NPTDVARS NPKSPQK - - - - - - - - - - - S151 VARSNPKS PQKPIVR 1.4e-8 - 1.8e-11 - - -0.014 -0.25 -0.9 - 4.5e-13 2.4e-4 T313 SLAETALT SGSSPSA 0.92 - - - - - 0.92 - - - - S316 ETALTSGS SPSAPAS - - - - - - - - - - - S319 LTSGSSPS APASDSI - - - - - - - - - - - S323 SSPSAPAS DSIGPQI - - - - - - - - - - - S325 PSAPASDS IGPQILT - - - - - - - - - - - T332 SIGPQILT SPSPSKS - - - - - - - - - - - S333 IGPQILTS PSPSKSI -1.5e-4 - - - - - -0.013 -0.027 - -0.059 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S76
S147
S151
T313
S316
S319
S323
S325
T332
S333
S335
S363
S364
S365
T373
T396
S399
T401
S405
S409
S429
S446
S447
S602
S607
S729
S744
Y746
S750
T753
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation CCRCC S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation COAD S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation GBM S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation HNSCC S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation LSCC S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation LUAD S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation OV S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation PDAC S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation UCEC S76 S147 S151 T313 S316 S319 S323 S325 T332 S333 S335 S363 S364 S365 T373 T396 S399 T401 S405 S409 S429 S446 S447 S602 S607 S729 S744 Y746 S750 T753 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S76
S147
S151
T313
S316
S319
S323
S325
T332
S333
S335
S363
S364
S365
T373
T396
S399
T401
S405
S409
S429
S446
S447
S602
S607
S729
S744
Y746
S750
T753
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S76
S147
S151
T313
S316
S319
S323
S325
T332
S333
S335
S363
S364
S365
T373
T396
S399
T401
S405
S409
S429
S446
S447
S602
S607
S729
S744
Y746
S750
T753
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.