IQSEC2: IQ motif and Sec7 domain ArfGEF 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S82 DPHGARDS PGRESQY 2 101 - - - - - - 95 - - - - - - - 6 - - - - - Y89 SPGRESQY QNLRETQ 1 19 - - - - - - 19 - - - - - - - - - - - - - S105 HHRELRES QFHQAAR 1 26 - - - - - - 26 - - - - - - - - - - - - - S213 SRGASRSS SPGAGGG 1 9 - - - - - - 9 - - - - - - - - - - - - - S214 RGASRSSS PGAGGGH 5 182 - - - - 5 4 64 - 11 7 5 4 - - 69 13 - - - - S224 AGGGHSTS TSTSPAT 1 9 - - - - - - 9 - - - - - - - - - - - - - S228 HSTSTSTS PATTLQR 1 18 - - - - - - 18 - - - - - - - - - - - - - S246 GENSRTVS VEGDAPG 8 379 - - 61 43 4 5 63 - 7 2 79 72 5 4 21 4 6 3 - - S262 DLSTAVDS PGSQPPY 2 80 - - - - - - 72 - - - - - - - - - - - 5 3 S302 RARLQPAS VALRKQE 2 46 - - - - - - - - - - - - 9 8 - - - - 25 4
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S82 DPHGARDS PGRESQY - - - - - - - - - - - Y89 SPGRESQY QNLRETQ - - - - - - - - - - - S105 HHRELRES QFHQAAR - - - - - - - - - - - S213 SRGASRSS SPGAGGG - - - - - - - - - - - S214 RGASRSSS PGAGGGH 0.61 - - - - - - - 0.61 - - S224 AGGGHSTS TSTSPAT - - - - - - - - - - - S228 HSTSTSTS PATTLQR - - - - - - - - - - - S246 GENSRTVS VEGDAPG -0.045 - -9.0e-4 - - - 0.63 - - - - S262 DLSTAVDS PGSQPPY - - - - - - - - - - - S302 RARLQPAS VALRKQE - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S82
Y89
S105
S213
S214
S224
S228
S246
S262
S302
S322
Y323
S326
S344
S372
S373
S393
S412
S435
T448
S463
S470
S474
S484
S493
S512
S528
S600
S603
S614
S627
S691
S698
S720
S741
S744
S1107
S1115
S1124
S1143
S1148
S1158
S1161
S1173
S1194
S1199
S1203
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation CCRCC S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation COAD S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation GBM S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation HNSCC S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation LSCC S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation LUAD S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation OV S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation PDAC S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation UCEC S82 Y89 S105 S213 S214 S224 S228 S246 S262 S302 S322 Y323 S326 S344 S372 S373 S393 S412 S435 T448 S463 S470 S474 S484 S493 S512 S528 S600 S603 S614 S627 S691 S698 S720 S741 S744 S1107 S1115 S1124 S1143 S1148 S1158 S1161 S1173 S1194 S1199 S1203 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S82
Y89
S105
S213
S214
S224
S228
S246
S262
S302
S322
Y323
S326
S344
S372
S373
S393
S412
S435
T448
S463
S470
S474
S484
S493
S512
S528
S600
S603
S614
S627
S691
S698
S720
S741
S744
S1107
S1115
S1124
S1143
S1148
S1158
S1161
S1173
S1194
S1199
S1203
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S82
Y89
S105
S213
S214
S224
S228
S246
S262
S302
S322
Y323
S326
S344
S372
S373
S393
S412
S435
T448
S463
S470
S474
S484
S493
S512
S528
S600
S603
S614
S627
S691
S698
S720
S741
S744
S1107
S1115
S1124
S1143
S1148
S1158
S1161
S1173
S1194
S1199
S1203
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.