ISG15: ISG15 ubiquitin like modifier
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1z2m chain A
2hj8 chain A
3phx chain B
3pse chain B
3r66 chain C
3r66 chain D
3rt3 chain B
3sdl chain C
3sdl chain D
5tl6 chain A
5tl6 chain C
5w8t chain B
5w8t chain D
5w8u chain B
5w8u chain D
6bi8 chain C
6bi8 chain D
6ffa chain B
6xa9 chain B
6xa9 chain D
6xa9 chain F
7rbs chain B
7rbs chain D
7rbs chain F
7rbs chain H
7rbs chain J
7s6p chain A
7s6p chain B
7s6p chain C
7s6p chain D
7s6p chain E
7s6p chain F
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S50 QRLAVHPS GVALQDR 1 8 - - - - - - - - - - - - - - 7 1 - - - - S93 VRNNKGRS STYEVRL 3 23 - - - - - - - - 5 3 - - - - 7 2 5 1 - - S94 RNNKGRSS TYEVRLT 4 93 8 - - - - - - - - - 10 8 4 4 48 11 - - - - T95 NNKGRSST YEVRLTQ 1 17 - - - - - - - - - - - - - - 14 3 - - - -
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S50 QRLAVHPS GVALQDR - - - - - - - - - - - S93 VRNNKGRS STYEVRL - - - - - - - - - - - S94 RNNKGRSS TYEVRLT 0.34 - - - - - - - 0.34 - - T95 NNKGRSST YEVRLTQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S50
S93
S94
T95
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S50 S93 S94 T95 protein RNA SCNV methylation CCRCC S50 S93 S94 T95 protein RNA SCNV methylation COAD S50 S93 S94 T95 protein RNA SCNV methylation GBM S50 S93 S94 T95 protein RNA SCNV methylation HNSCC S50 S93 S94 T95 protein RNA SCNV methylation LSCC S50 S93 S94 T95 protein RNA SCNV methylation LUAD S50 S93 S94 T95 protein RNA SCNV methylation OV S50 S93 S94 T95 protein RNA SCNV methylation PDAC S50 S93 S94 T95 protein RNA SCNV methylation UCEC S50 S93 S94 T95 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S50
S93
S94
T95
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S50
S93
S94
T95
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.