IGF1R: insulin like growth factor 1 receptor
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1igr chain A
1jqh chain A
1jqh chain B
1jqh chain C
1k3a chain A
1m7n chain A
1m7n chain B
1p4o chain A
1p4o chain B
2oj9 chain A
2zm3 chain A
2zm3 chain B
2zm3 chain C
2zm3 chain D
3d94 chain A
3f5p chain A
3f5p chain B
3f5p chain C
3f5p chain D
3f5p chain E
3f5p chain F
3f5p chain G
3f5p chain H
3f5p chain I
3f5p chain J
3f5p chain K
3f5p chain L
3f5p chain M
3f5p chain R
3f5p chain S
3f5p chain T
3i81 chain A
3lvp chain A
3lvp chain B
3lvp chain C
3lvp chain D
3lw0 chain A
3lw0 chain B
3lw0 chain C
3lw0 chain D
3nw5 chain A
3nw6 chain A
3nw7 chain A
3o23 chain A
3qqu chain A
3qqu chain B
3qqu chain C
3qqu chain D
4d2r chain A
4xss chain F
5fxq chain A
5fxr chain A
5fxs chain A
5hzn chain A
5hzn chain B
5hzn chain C
5hzn chain D
5hzn chain E
5hzn chain F
5hzn chain G
5hzn chain H
5u8q chain A
5u8r chain A
6jk8 chain A
6jk8 chain B
6vwg chain A
6vwg chain B
6vwh chain A
6vwh chain B
6vwi chain A
6vwi chain B
6vwj chain A
6vwj chain B
7ph8 chain A
7s0q chain A
7s8v chain A
7v3p chain A
7v3p chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T53 LKRLENCT VIEGYLH 1 7 - - - - - - - - - - - - - - - - - - 7 - Y58 NCTVIEGY LHILLIS 1 7 - - - - - - - - - - - - - - - - - - 7 - Y673 DKIPIRKY ADGTIDI 1 8 - - - - - - - - - - - - - - - - - - 6 2 S1009 SRELGQGS FGMVYEG 2 17 8 - - - - - 9 - - - - - - - - - - - - - S1302 LEPENMES VPLDPSA 3 44 17 - 8 - - - - - 12 7 - - - - - - - - - - S1308 ESVPLDPS ASSSSLP 1 8 - - 4 4 - - - - - - - - - - - - - - - - S1310 VPLDPSAS SSSLPLP 2 33 - - 4 4 - - - - - - - - - - - - - - 12 13 S1312 LDPSASSS SLPLPDR 1 9 - - - - - - - - - - - - - - - - - - - 9 S1313 DPSASSSS LPLPDRH 6 105 6 - 5 4 - - - - 21 13 15 15 - - - - 7 3 12 4 S1339 GVLVLRAS FDERQPY 6 306 87 - 13 12 - - - - 75 47 29 27 5 4 - - 5 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T53 LKRLENCT VIEGYLH - - - - - - - - - - - Y58 NCTVIEGY LHILLIS - - - - - - - - - - - Y673 DKIPIRKY ADGTIDI - - - - - - - - - - - S1009 SRELGQGS FGMVYEG - - - - - - - - - - - S1302 LEPENMES VPLDPSA - - - - - - - - - - - S1308 ESVPLDPS ASSSSLP - - - - - - - - - - - S1310 VPLDPSAS SSSLPLP - - - - - - - - - - - S1312 LDPSASSS SLPLPDR - - - - - - - - - - - S1313 DPSASSSS LPLPDRH 0.78 - - - - 0.78 - - - - - S1339 GVLVLRAS FDERQPY 9e-7 - - - - 4.1e-4 6.5e-4 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T53
Y58
Y673
S1009
S1302
S1308
S1310
S1312
S1313
S1339
S1365
T1366
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation CCRCC T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation COAD T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation GBM T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation HNSCC T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation LSCC T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation LUAD T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation OV T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation PDAC T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation UCEC T53 Y58 Y673 S1009 S1302 S1308 S1310 S1313 S1339 S1365 T1366 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T53
Y58
Y673
S1009
S1302
S1308
S1310
S1312
S1313
S1339
S1365
T1366
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T53
Y58
Y673
S1009
S1302
S1308
S1310
S1312
S1313
S1339
S1365
T1366
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.