Protein: ENSP00000498083
Gene: MKNK1

LinkedOmicsKB © 2022-2023 Zhang Lab

MKNK1:
MAPK interacting serine/threonine kinase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T37KKRRGRATDSLPGKF134----------------2311--
S39RRGRATDSLPGKFED101041104-7452212489-10359948771646274317115
S221PENILCESPEKVSPV71021--7560--90-1086210394110101--100416116
S226CESPEKVSPVKICDF7197--44--37-641091717--542114-
T246MKLNNSCTPITTPEL322------8---------4172
T250NSCTPITTPELTTPC327------8-5455--------
T385APEKGLPTPQVLQRN7290--54--17-12533304744--4220274
S394QVLQRNSSTMDLTLF217--44--9-------------
T395VLQRNSSTMDLTLFA19------9-------------
S413IALNRQLSQHEENEL7728--4938--9-884864599286--94384716
Showing 1 to 10 of 13 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T37KKRRGRATDSLPGKF-9.1e-4---------9.1e-4-
S39RRGRATDSLPGKFED-1.2e-7-3.2e-18-0.051-0.75-1.5e-20-1.3e-4--3.6e-12-0.6
S221PENILCESPEKVSPV2.9e-10-5.8e-3--1.9e-107.7e-71.2e-5--7.5e-133.2e-5
S226CESPEKVSPVKICDF-5.7e-6---------5.7e-6-
T246MKLNNSCTPITTPEL-----------
T250NSCTPITTPELTTPC-----------
T385APEKGLPTPQVLQRN0.57------0.70.11--0.82-
S394QVLQRNSSTMDLTLF-----------
T395VLQRNSSTMDLTLFA-----------
S413IALNRQLSQHEENEL6.9e-3--0.5--0.210.325.1e-5--0.540.11
Showing 1 to 10 of 13 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationCCRCCT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationCOADT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationGBMT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationHNSCCT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationLSCCT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationLUADT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationOVT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationPDACT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylationUCECT37S39S221S226T246T250T385S394T395S413S433S437S460proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.