Protein: ENSP00000498360

MYD88:: MYD88 innate immune signal transduction adaptor

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S244	TKFALSLSPGAHQKR	5	230	15	-	-	-	11	7	45	-	90	54	-	-	-	-	6	2	-	-	-	-

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Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S244	TKFALSLSPGAHQKR	4.3e-5	-	-	-	-	4.3e-5	-	-	-	-	-

Showing 1 to 1 of 1 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
SBS7b (UVR)	S244	1.3e-3	0.02	-	-	-	0.026	-	-	-	-	-
KINASE-PSP_ERK2/MAPK1	S244	2.7e-3	0.2	-	-0.99	0.023	0.014	-	-	-	-	-
PROGENy: PI3K	S244	4.1e-3	0.2	-	-0.34	0.025	1.6e-3	-	-	-	-	-
PERT-PSP_NOCODAZOLE	S244	0.005	0.12	-	-0.58	0.058	6.7e-3	-	-	-	-	-
KINASE-PSP_CDK2	S244	7.2e-3	0.25	-	0.9	0.44	8.6e-4	-	-	-	-	-
KINASE-PSP_mTOR/MTOR	S244	8.2e-3	0.14	-	-	0.011	0.58	-	-	-	-	-
KINASE-PSP_P38A/MAPK14	S244	0.019	-	-	-	0.17	0.054	-	-	-	-	-
HALLMARK_P53_PATHWAY	S244	0.022	0.23	-	-0.97	0.13	0.055	-	-	-	-	-
KINASE-PSP_CDK1	S244	0.026	0.47	-	-0.84	0.12	0.018	-	-	-	-	-
SBS7a (UVR)	S244	0.027	0.37	-	-	-	0.026	-	-	-	-	-

Showing 1 to 10 of 258 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
RPS6KB2	S244	2.4e-4	0.24	-	-	0.012	7.8e-3	-	-	-	-	-
MKNK1	S244	1.1e-3	4.1e-3	-	-	0.49	0.035	-	-	-	-	-
BAZ1A	S244	2.1e-3	-0.47	-	0.2	0.027	7.2e-4	-	-	-	-	-
EPHA1	S244	2.3e-3	-	-	-	-	2.3e-3	-	-	-	-	-
MAP3K11	S244	2.9e-3	0.031	-	-	0.051	0.29	-	-	-	-	-
PLK1	S244	3.1e-3	0.15	-	-	0.09	0.048	-	-	-	-	-
CDK10	S244	3.2e-3	-	-	-	-	3.2e-3	-	-	-	-	-
PKN2	S244	5.1e-3	0.28	-	0.26	0.35	0.014	-	-	-	-	-
RIOK1	S244	5.3e-3	0.15	-	-	0.37	0.013	-	-	-	-	-
CERT1	S244	6.6e-3	0.24	-	0.19	0.82	6.3e-3	-	-	-	-	-

Showing 1 to 10 of 538 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
PTP4A2	S244	-4.4e-3	-0.7	-	-0.27	-0.027	-0.045	-	-	-	-	-
PPM1A	S244	-6.9e-3	0.96	-	-0.71	-0.24	-8.9e-5	-	-	-	-	-
PDP2	S244	-0.014	-	-	-	-0.024	-0.23	-	-	-	-	-
IMPAD1	S244	-0.016	-0.79	-	1	-0.045	-0.057	-	-	-	-	-
NT5C	S244	-0.018	0.88	-	-0.31	-0.12	-0.021	-	-	-	-	-
TIMM50	S244	-0.019	-0.012	-	-0.14	-0.025	0.12	-	-	-	-	-
PNKP	S244	-0.026	-0.55	-	-0.4	-0.1	-0.17	-	-	-	-	-
PPM1E	S244	-0.03	-0.081	-	-	-0.19	-	-	-	-	-	-
OCRL	S244	-0.03	-0.19	-	-0.58	-0.083	-0.47	-	-	-	-	-
SYNJ1	S244	-0.032	0.98	-	-	-0.12	-0.03	-	-	-	-	-

Showing 1 to 10 of 240 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000498360Gene: MYD88

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000498360
Gene: MYD88