DOCK9: dedicator of cytokinesis 9
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1wg7 chain A
2wm9 chain A
2wmn chain A
2wmo chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S21 RKFTRALS KPGTAAE 3 178 - - - - - - - - - - 40 36 47 45 - - 6 4 - - S32 TAAELRQS VSEVVRG 6 512 - - 23 23 - - - - 63 34 83 76 75 69 - - 16 5 34 11 S34 AELRQSVS EVVRGSV 2 17 - - 4 3 - - - - 6 4 - - - - - - - - - - S40 VSEVVRGS VLLAKPK 3 54 - - 4 4 - - - - - - 20 18 4 4 - - - - - - T83 FPYDDFQT AILRRQG 1 7 - - - - - - - - - - - - 4 3 - - - - - - S119 ECIKTYNS DWHLVNY 1 19 - - - - - - - - - - 10 9 - - - - - - - - S167 DKDEDAAS LGSQKGG 10 1090 96 - 95 80 8 10 71 - 108 62 88 80 98 87 7 1 77 34 72 16 S170 EDAASLGS QKGGITK 8 1047 89 - 95 73 - - 90 - 102 59 98 89 94 85 - - 51 21 83 18 S308 EQSKLEGS GSGLDSY 7 285 - - - - 4 5 72 - 5 4 30 27 22 20 - - 38 18 27 13 S310 SKLEGSGS GLDSYLP 9 228 38 - 5 4 - - 9 - 10 7 19 18 31 28 19 5 5 2 26 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S21 RKFTRALS KPGTAAE -2.9e-7 - - - - - -6.1e-7 -0.023 - - - S32 TAAELRQS VSEVVRG -6.8e-20 - -0.19 - - -4.0e-4 -1.7e-17 -1.0e-4 - - -1.5e-3 S34 AELRQSVS EVVRGSV - - - - - - - - - - - S40 VSEVVRGS VLLAKPK -5.4e-8 - - - - - -5.4e-8 - - - - T83 FPYDDFQT AILRRQG - - - - - - - - - - - S119 ECIKTYNS DWHLVNY - - - - - - - - - - - S167 DKDEDAAS LGSQKGG -2.2e-15 - 8.5e-4 - - -2e-15 -4e-23 -3.1e-25 - 1.4e-4 0.097 S170 EDAASLGS QKGGITK -4.8e-7 - 0.033 - - -5.7e-7 -5.4e-8 -3.2e-16 - -0.93 2.4e-5 S308 EQSKLEGS GSGLDSY -9.3e-6 - - - - - -1.3e-12 -1.1e-7 - 2.4e-5 -0.49 S310 SKLEGSGS GLDSYLP -1.3e-14 - - - - - - -1.3e-14 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S21
S32
S34
S40
T83
S119
S167
S170
S308
S310
T431
S433
S440
S443
S927
Y959
S960
S970
S1186
T1211
T1217
S1221
S1235
T1238
T1239
S1240
T1241
S1246
S1252
S1255
S1258
T1259
S1261
S1264
S1270
S1273
S1275
S1282
S1283
S1288
S1564
S1566
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation CCRCC S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation COAD S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation GBM S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation HNSCC S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation LSCC S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation LUAD S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation OV S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation PDAC S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation UCEC S21 S32 S34 S40 T83 S119 S167 S170 S308 S310 T431 S433 S440 S443 S927 Y959 S960 S970 S1186 T1211 T1217 S1221 S1235 T1238 T1239 S1240 T1241 S1246 S1252 S1255 S1258 T1259 S1261 S1264 S1270 S1273 S1275 S1282 S1283 S1288 S1564 S1566 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S21
S32
S34
S40
T83
S119
S167
S170
S308
S310
T431
S433
S440
S443
S927
Y959
S960
S970
S1186
T1211
T1217
S1221
S1235
T1238
T1239
S1240
T1241
S1246
S1252
S1255
S1258
T1259
S1261
S1264
S1270
S1273
S1275
S1282
S1283
S1288
S1564
S1566
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S21
S32
S34
S40
T83
S119
S167
S170
S308
S310
T431
S433
S440
S443
S927
Y959
S960
S970
S1186
T1211
T1217
S1221
S1235
T1238
T1239
S1240
T1241
S1246
S1252
S1255
S1258
T1259
S1261
S1264
S1270
S1273
S1275
S1282
S1283
S1288
S1564
S1566
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.