ARHGAP35: Rho GTPase activating protein 35
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2k85 chain A
3c5h chain A
3fk2 chain A
3fk2 chain B
3fk2 chain C
3fk2 chain D
6pxc chain U
6way chain V
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S589 SDRNQKNS LSDPNID 9 538 8 - - - 45 36 81 - 11 6 25 23 18 16 64 13 59 26 89 18 S591 RNQKNSLS DPNIDRI 4 60 25 - 5 4 - - - - - - 9 9 4 4 - - - - - - S769 KRNLNLVS STASIKD 9 395 28 - 21 20 26 19 35 - 38 25 19 17 16 17 - - 67 28 19 - S770 RNLNLVSS TASIKDL 10 1012 84 - 42 39 81 89 27 - 58 33 85 79 83 76 56 12 82 33 47 6 T771 NLNLVSST ASIKDLA 9 240 7 - 31 25 11 15 9 - 29 16 25 22 4 4 - - 24 12 6 - S773 NLVSSTAS IKDLADV 10 531 70 - 9 8 23 22 91 - 6 4 10 9 12 11 21 4 84 34 95 18 Y954 IIEATHMY DNAAEAC 4 55 8 - 20 11 - - 9 - 5 2 - - - - - - - - - - S962 DNAAEACS TTEEVFN 8 322 71 - 36 34 - - 72 - 6 4 15 14 16 16 - - 5 3 21 9 T963 NAAEACST TEEVFNS 1 26 26 - - - - - - - - - - - - - - - - - - - S970 TTEEVFNS PRAGSPL 10 1095 104 - 28 25 49 58 99 - 67 39 77 73 88 81 61 14 96 41 77 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S589 SDRNQKNS LSDPNID -4.1e-3 - - -0.17 - - -0.016 - -1.6e-3 -0.77 0.41 S591 RNQKNSLS DPNIDRI - - - - - - - - - - - S769 KRNLNLVS STASIKD 0.69 - -2.9e-3 0.46 - 9.6e-14 - - - -1.7e-9 - S770 RNLNLVSS TASIKDL 2.7e-7 - -1.1e-4 0.014 - 2.4e-13 9.8e-12 0.086 0.46 -0.12 - T771 NLNLVSST ASIKDLA 0.65 - -0.005 - - 1.6e-7 6.6e-3 - - -2.1e-5 - S773 NLVSSTAS IKDLADV -0.017 - - 0.74 - - - - - -4.1e-3 -0.12 Y954 IIEATHMY DNAAEAC -0.48 - -0.48 - - - - - - - - S962 DNAAEACS TTEEVFN 0.87 - 0.87 - - - - - - - - T963 NAAEACST TEEVFNS - - - - - - - - - - - S970 TTEEVFNS PRAGSPL -2.7e-12 - -0.19 -0.068 - -1e-7 -9e-11 -2.6e-4 0.065 -0.26 -0.056
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S589
S591
S769
S770
T771
S773
Y954
S962
T963
S970
S975
S980
S985
T1000
S1001
S1010
S1013
S1023
S1070
S1073
S1074
S1085
Y1087
Y1105
S1130
S1134
S1136
S1141
S1142
S1150
S1174
S1176
S1179
S1195
S1236
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation CCRCC S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation COAD S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation GBM S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation HNSCC S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation LSCC S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation LUAD S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation OV S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation PDAC S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation UCEC S589 S591 S769 S770 T771 S773 Y954 S962 T963 S970 S975 S980 S985 T1000 S1001 S1010 S1013 S1023 S1070 S1073 S1074 S1085 Y1087 Y1105 S1130 S1134 S1136 S1141 S1142 S1150 S1174 S1176 S1179 S1195 S1236 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S589
S591
S769
S770
T771
S773
Y954
S962
T963
S970
S975
S980
S985
T1000
S1001
S1010
S1013
S1023
S1070
S1073
S1074
S1085
Y1087
Y1105
S1130
S1134
S1136
S1141
S1142
S1150
S1174
S1176
S1179
S1195
S1236
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S589
S591
S769
S770
T771
S773
Y954
S962
T963
S970
S975
S980
S985
T1000
S1001
S1010
S1013
S1023
S1070
S1073
S1074
S1085
Y1087
Y1105
S1130
S1134
S1136
S1141
S1142
S1150
S1174
S1176
S1179
S1195
S1236
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.