Basic information
- Phenotype
- HALLMARK_MYC_TARGETS_V2
- Description
- Enrichment score representing targets regulated by MYC (version 2). The score was calculated using ssGSEA on the RNA data (Z-score transformed coding genes with expression in at least 50% of the samples in a cohort).
- Source
- http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2.html
- Method
- Single sample gene set enrichment analysis (ssGSEA) was performed for each cancer type using gene-wise Z-scores of the RNA expression data (RSEM) for the MSigDB Hallmark gene sets v7.0 (PMID: 26771021) via the ssGSEA2.0 R package (PMID: 30563849). RNA data were filtered to coding genes with < 50% 0 expression. (Parameters: sample.norm.type="rank", weight=0.75, statistic="area.under.RES", nperm=1000, min.overlap=10). Pathway activity scores are normalized enrichment scores from ssGSEA.
- Genes
-
- BYSL
- CBX3
- CDK4
- DCTPP1
- DDX18
- DUSP2
- EXOSC5
- FARSA
- GNL3
- GRWD1
- HK2
- HSPD1
- HSPE1
- IMP4
- IPO4
- LAS1L
- MAP3K6
- MCM4
- MCM5
- MPHOSPH10
- MRTO4
- MYBBP1A
- MYC
- NDUFAF4
- NIP7
- NOC4L
- NOLC1
- NOP16
- NOP2
- NOP56
- NPM1
- PA2G4
- PES1
- PHB
- PLK1
- PLK4
- PPAN
- PPRC1
- PRMT3
- PUS1
- RABEPK
- RCL1
- RRP12
- RRP9
- SLC19A1
- SLC29A2
- SORD
- SRM
- SUPV3L1
- TBRG4
- TCOF1
- TFB2M
- TMEM97
- UNG
- UTP20
- WDR43
- WDR74
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with HALLMARK_MYC_TARGETS_V2 to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with HALLMARK_MYC_TARGETS_V2 to WebGestalt.