Gene: MCM4

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
minichromosome maintenance complex component 4
Ensembl
ENSG00000104738.18
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.8e-73-0.19--7.3e-192e-348.2e-34-2.1e-9-
protein3.0e-115-2.7e-281.8e-25-5.7e-132.4e-345.2e-245.6e-86.2e-90.022

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.51313.51414.51515.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2323.52424.52525.52626.52727.52828.52929.530log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer0204060801001201401601800-20-40-60-80-100-120-140-160-180proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MCM4 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_G2M_CHECKPOINT5.2e-1572.2e-168.8e-102.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-161.7e-36
HALLMARK_E2F_TARGETS2.0e-1512.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-192.2e-16
KINASE-PSP_CDK22.7e-1152.2e-167.8e-56.4e-92.2e-162.2e-162.2e-162.2e-167.3e-72.2e-162.2e-16
HALLMARK_MYC_TARGETS_V24.8e-916.5e-161.7e-41.9e-53.8e-112.2e-162.2e-162.2e-169.7e-43e-72.2e-16
HALLMARK_MYC_TARGETS_V13.3e-842.2e-164.0e-58.2e-52.2e-165.8e-52.2e-162.2e-160.0036.5e-82.2e-16
HALLMARK_SPERMATOGENESIS7.4e-772.2e-160.0362.2e-164.9e-42.2e-162.2e-162.2e-161.5e-54.4e-31.1e-6
KINASE-PSP_CDK13.1e-712.2e-160.32.0e-42.2e-164e-82.3e-92.2e-162.5e-59.5e-81.7e-9
HALLMARK_DNA_REPAIR9e-682.6e-68.7e-41.1e-42.2e-162.8e-82.2e-161.7e-80.0411.6e-72.2e-16
PERT-PSP_NOCODAZOLE5.4e-621.7e-200.050.428.3e-62.2e-102.2e-162.2e-162.4e-44.1e-53.9e-8
HALLMARK_MITOTIC_SPINDLE6.9e-582.2e-92.2e-30.472.2e-164.5e-41.1e-32.2e-163.4e-42.3e-92.2e-16
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MCM4

BRCA0.660.270.55proteinmRNASCNVmethylationCCRCC0.660.240.320.260.500.17proteinmRNASCNVmethylationCOAD0.60-0.090.40proteinmRNASCNVmethylationGBM0.830.15-0.270.09-0.12-0.18proteinmRNASCNVmethylationHNSCC0.590.030.08-0.040.440.12proteinmRNASCNVmethylationLSCC0.65-0.010.20-0.040.64-0.00proteinmRNASCNVmethylationLUAD0.76-0.040.09-0.040.390.00proteinmRNASCNVmethylationOV0.69-0.030.49proteinmRNASCNVmethylationPDAC0.760.14-0.060.040.18-0.16proteinmRNASCNVmethylationUCEC0.83-0.190.02-0.050.210.25proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MCM4 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.