Basic information
- Phenotype
- PROGENy: Trail
- Description
- Score representing the activity of the TRAIL pathway. It was calculated using the PROGENy tool on the RNA data (genes with mean FPKM expression >0).
- Source
- https://www.nature.com/articles/s41467-017-02391-6; https://www.sciencedirect.com/science/article/abs/pii/S1874939919302287?via%3Dihub
- Method
- The PROGENy scores were inferred using the R package progeny (V1.10.0) (PMID: 29295995) with default parameters using the RNA expression data (FPKM). Genes with mean expression = 0 in a cohort were removed from the analysis.
- Genes
-
- LSM12
- MS4A1
- MYOC
- NDST3
- NFAM1
- NPW
- NPY
- OR5K1
- PDAP1
- RAB37
- RAG2
- RGSL1
- RHEBL1
- RNF175
- RRP12
- SCNN1D
- SLC7A9
- SPINK2
- TAS2R5
- Array
- TAS2R9
- TEC
- TESPA1
- TLDC2
- TLR10
- Array
- TMEM259
- TMEM74
- TRIM72
- UAP1L1
- VHL
- WDR97
- WFDC10A
- Array
- WNT8A
- ZIM3
- ZNRF4
- Array
- Array
- ADAMTS17
- AGAP6
- BACH2
- BHMT
- BRS3
- C17orf99
- C7orf77
- CALML6
- CBFA2T3
- CCDC155
- CD1A
- CST7
- CXorf56
- DDX19A
- DMRTC2
- DNAJB8
- FLCN
- FRMPD1
- HTR1F
- HVCN1
- Array
- Array
- Array
- GLIPR1L1
- GNL3L
- GPR18
- Array
- IFNLR1
- KCNA5
- Array
- KCNAB3
- KLHL14
- Array
- KRT35
- LIM2
- Array
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with PROGENy: Trail to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with PROGENy: Trail to WebGestalt.