Basic information
- Phenotype
- xcell: Neutrophil
- Description
- Enrichment score inferring the proportion of neutrophils in the tumor derived from RNA data using the xCell tool.
- Source
- https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1349-1
- Method
- The R package immunedeconv (V2.0.4) (PMID: 31510660) was used to perform immune cell deconvolution using RNA expression data (TPM).
- Genes
-
- ACAP2
- APAF1
- BEST1
- BMX
- BTN2A1
- BTNL8
- CA4
- CAMKK2
- CASP5
- CBL
- CEACAM3
- CEACAM8
- CIR1
- CLC
- CLEC4E
- CSF2RB
- CSF3R
- CXCR1
- CXCR2
- DDX3X
- DHX34
- ELL
- FBXO38
- FCAR
- FCGR3B
- FPR2
- GCC1
- GPR27
- HBB
- HERC3
- HRH4
- HSPA6
- IL18RAP
- IP6K1
- KSR1
- LILRA1
- LILRA2
- LILRB2
- LMTK2
- MAK
- MED13L
- MEFV
- MMP25
- MTMR3
- NDEL1
- NFYA
- NMI
- NRBF2
- P2RY13
- PADI4
- PAK2
- PGLYRP1
- PTEN
- RMND5A
- S100A12
- SDF2
- SLC19A1
- SLC25A44
- SPAG9
- TECPR2
- TGM3
- TMEM185B
- TMUB2
- TOP1
- TOX4
- TREM1
- TREML2
- TRIM25
- TRPM6
- TTLL4
- UBE2B
- UBE2D1
- UBN1
- UBXN2B
- USP15
- VNN3
- WDFY3
- WWP2
- ZDHHC18
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with xcell: Neutrophil to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with xcell: Neutrophil to WebGestalt.