Gene: DDX3X

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
DEAD-box helicase 3 X-linked
Ensembl
ENSG00000215301.10
Summary
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Annotation
Cancer driver (TSG)

Protein product

  • ENST00000644876.1 Primary ENSP00000494040.1 (35 phosphosites)
  • ENST00000629496.3
  • ENST00000646122.1
  • ENST00000626301.2
  • ENST00000441189.4
  • ENST00000644677.1
  • ENST00000646107.1
  • ENST00000642424.1
  • ENST00000642322.1
  • ENST00000646627.1
  • ENST00000646679.1
  • ENST00000643821.1
  • ENST00000625837.2
  • ENST00000644109.1
  • ENST00000644513.1
  • ENST00000399959.7
  • ENST00000646319.1
  • ENST00000644074.1
  • ENST00000644073.1
  • ENST00000457138.7
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-6.1e-6-7.2e-3---3.8e-3-1.5e-6-1.1e-9-0.32-
protein1.8e-67-5.2e-41.7e-20-6.3e-62.5e-325.4e-301.0e-60.883.6e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC10.51111.51212.51313.51414.51515.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer0510152025303540450-5-10-15-20-25-30-35-40-45proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DDX3X with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Clinical: Sex5.4e-40-6.2e-66.2e-82.4e-57.2e-61.7e-51.1e-5-1.6e-14-
HALLMARK_G2M_CHECKPOINT3.1e-241.1e-90.0690.0363.8e-50.533.0e-40.0372.3e-35.0e-55.0e-6
HALLMARK_E2F_TARGETS9.8e-245.4e-80.0740.0111.8e-50.752.9e-40.0190.0067.4e-52.6e-6
KINASE-PSP_CDK21.6e-193.8e-63.9e-31.5e-34.6e-30.151.1e-30.0450.162.1e-39.6e-5
PROGENy: PI3K2.6e-195.9e-61.6e-30.182.1e-35.8e-80.240.480.0262.4e-31.8e-4
KINASE-PSP_CDK12.5e-182.6e-100.713.9e-32.4e-30.0180.020.0190.0630.0473.8e-5
HALLMARK_MYC_TARGETS_V22.9e-188.9e-90.170.0397.5e-53.9e-34.7e-30.120.870.0174.4e-6
HALLMARK_MTORC1_SIGNALING1.2e-162.6e-60.0840.0350.120.163.3e-30.055.2e-32.4e-37.4e-5
PERT-PSP_NOCODAZOLE1.3e-161.5e-60.210.0410.0781.4e-37.2e-30.447.2e-31.6e-31.5e-4
xcell: T cell CD4+ Th22.2e-151.1e-70.0440.113.4e-40.670.010.250.0147.9e-39.8e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DDX3X

BRCA0.17-0.010.35proteinmRNASCNVmethylationCCRCC0.42-0.340.30-0.400.17-0.15proteinmRNASCNVmethylationCOAD0.450.050.14proteinmRNASCNVmethylationGBM0.41-0.300.06-0.390.23-0.17proteinmRNASCNVmethylationHNSCC0.60-0.190.05-0.290.22-0.20proteinmRNASCNVmethylationLSCC0.55-0.290.29-0.410.44-0.15proteinmRNASCNVmethylationLUAD0.44-0.180.20-0.370.20-0.11proteinmRNASCNVmethylationOV0.370.280.56proteinmRNASCNVmethylationPDAC0.73-0.01-0.33-0.01-0.24-0.14proteinmRNASCNVmethylationUCEC0.23-0.120.16-0.250.38-0.19proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DDX3X and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.