Basic information

Full name
anaphase promoting complex subunit 2
Ensembl
ENSG00000176248.9
Summary
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.3e-11--3.5e-6---0.47-2.1e-5-0.031--1.5e-3-
protein0.25-1.1e-4-0.76-2.5e-90.0770.64-1.9e-3-1.9e-8-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC55.566.577.588.599.51010.511log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDAC2020.52121.52222.52323.52424.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567890-1-2-3-4-5-6-7-8-9Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ANAPC2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK29.7e-6-0.960.670.024.1e-35.8e-40.270.89-0.851.3e-3-
HALLMARK_E2F_TARGETS1.6e-50.560.240.510.0279.6e-39.6e-30.440.580.069-
HALLMARK_G2M_CHECKPOINT3.4e-50.530.30.925.1e-30.0696.6e-30.530.360.074-
KINASE-PSP_CK2A1/CSNK2A14.6e-50.220.860.130.640.022.7e-40.63-0.593.6e-3-
Tumor Purity (WGS)7.0e-5-0.043-8.6e-60.0160.250.98--0.75-
HALLMARK_MITOTIC_SPINDLE2.6e-40.1-0.960.190.0140.140.0930.80.520.12-
xcell: T cell CD4+ Th26.3e-40.90.1-0.520.0510.211.3e-50.280.860.75-
HALLMARK_DNA_REPAIR7.3e-40.350.36-0.650.235.1e-30.0110.042-0.560.44-
HALLMARK_MYC_TARGETS_V28.1e-40.480.80.520.19.5e-40.0010.51-0.0480.13-
PERT-PSP_UV8.5e-4----8.5e-4-----
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ANAPC2

BRCA0.270.110.41proteinmRNASCNVmethylationCCRCC0.120.070.09-0.120.57-0.04proteinmRNASCNVmethylationCOAD0.310.070.44proteinmRNASCNVmethylationGBM0.22-0.040.06-0.310.28-0.23proteinmRNASCNVmethylationHNSCC0.170.090.39-0.050.61-0.07proteinmRNASCNVmethylationLSCC0.280.160.23-0.080.63-0.02proteinmRNASCNVmethylationLUAD0.130.180.10-0.070.57-0.14proteinmRNASCNVmethylationOV0.240.290.61proteinmRNASCNVmethylationPDAC0.13-0.070.33-0.210.45-0.09proteinmRNASCNVmethylationUCEC-0.200.47-0.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ANAPC2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.