Basic information
- Full name
- anaphase promoting complex subunit 2
- Ensembl
- ENSG00000176248.9
- Summary
- A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
- Annotation
- Essential genes
Protein product
- ENST00000323927.3 Primary ENSP00000314004.2 (12 phosphosites)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -2.3e-11 | - | -3.5e-6 | - | - | -0.47 | -2.1e-5 | -0.031 | - | -1.5e-3 | - |
protein | 0.25 | - | 1.1e-4 | -0.76 | - | 2.5e-9 | 0.077 | 0.64 | -1.9e-3 | -1.9e-8 | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of ANAPC2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_CDK2 | 9.7e-6 | -0.96 | 0.67 | 0.02 | 4.1e-3 | 5.8e-4 | 0.27 | 0.89 | -0.85 | 1.3e-3 | - | |
HALLMARK_E2F_TARGETS | 1.6e-5 | 0.56 | 0.24 | 0.51 | 0.027 | 9.6e-3 | 9.6e-3 | 0.44 | 0.58 | 0.069 | - | |
HALLMARK_G2M_CHECKPOINT | 3.4e-5 | 0.53 | 0.3 | 0.92 | 5.1e-3 | 0.069 | 6.6e-3 | 0.53 | 0.36 | 0.074 | - | |
KINASE-PSP_CK2A1/CSNK2A1 | 4.6e-5 | 0.22 | 0.86 | 0.13 | 0.64 | 0.02 | 2.7e-4 | 0.63 | -0.59 | 3.6e-3 | - | |
Tumor Purity (WGS) | 7.0e-5 | - | 0.043 | - | 8.6e-6 | 0.016 | 0.25 | 0.98 | - | -0.75 | - | |
HALLMARK_MITOTIC_SPINDLE | 2.6e-4 | 0.1 | -0.96 | 0.19 | 0.014 | 0.14 | 0.093 | 0.8 | 0.52 | 0.12 | - | |
xcell: T cell CD4+ Th2 | 6.3e-4 | 0.9 | 0.1 | -0.52 | 0.051 | 0.21 | 1.3e-5 | 0.28 | 0.86 | 0.75 | - | |
HALLMARK_DNA_REPAIR | 7.3e-4 | 0.35 | 0.36 | -0.65 | 0.23 | 5.1e-3 | 0.011 | 0.042 | -0.56 | 0.44 | - | |
HALLMARK_MYC_TARGETS_V2 | 8.1e-4 | 0.48 | 0.8 | 0.52 | 0.1 | 9.5e-4 | 0.001 | 0.51 | -0.048 | 0.13 | - | |
PERT-PSP_UV | 8.5e-4 | - | - | - | - | 8.5e-4 | - | - | - | - | - |
Cis-association
Associations between omics data of ANAPC2
Trans-association
Associations of the protein abundance of ANAPC2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.