Basic information

Full name
adaptor related protein complex 4 subunit epsilon 1
Ensembl
ENSG00000081014.11
Summary
This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.13--0.88--6.7e-52.5e-5-6.6e-8-0.46-
protein0.16-2.3e-7--1.2e-5-1.4e-11-1.1e-3-0.480.0229.1e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.512log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1717.51818.51919.52020.52121.52222.52323.524log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910110-1-2-3-4-5-6-7-8-9-10-11Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of AP4E1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Monocyte4.9e-170.425.4e-30.0321.6e-78.3e-86.5e-60.562.6e-30.890.05
PROGENy: EGFR3.6e-160.870.0330.166.9e-93.3e-90.017.2e-40.0170.290.32
HALLMARK_INFLAMMATORY_RESPONSE8.2e-14-0.640.0050.121e-81.2e-48.8e-50.60.0160.310.024
HALLMARK_APOPTOSIS1.8e-130.188.5e-3-0.624.3e-116.2e-58.9e-30.154.1e-30.490.11
HALLMARK_TNFA_SIGNALING_VIA_NFKB5.2e-12-0.740.0830.162.9e-86.1e-61.9e-40.210.170.210.19
HALLMARK_IL6_JAK_STAT3_SIGNALING6.1e-12-0.381.5e-30.0182.9e-81.6e-34.4e-40.740.0740.610.026
HALLMARK_COMPLEMENT2.6e-11-0.862.1e-30.194.5e-80.0155.2e-40.610.007-0.890.015
xcell: immune score1.1e-100.953.1e-40.0464.5e-80.164.4e-4-0.443.6e-3-0.980.024
xcell: Macrophage1.8e-100.318.1e-50.292.9e-80.0986.3e-3-0.920.01-0.550.019
PROGENy: TNFa2.3e-10-0.540.250.0528.7e-64.5e-32.3e-50.0310.220.570.036
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of AP4E1

BRCA0.300.250.29proteinmRNASCNVmethylationCCRCC0.400.210.040.020.09-0.09proteinmRNASCNVmethylationCOAD0.400.310.48proteinmRNASCNVmethylationGBM0.36-0.000.270.030.480.15proteinmRNASCNVmethylationHNSCC0.700.090.41-0.020.50-0.12proteinmRNASCNVmethylationLSCC0.370.010.34-0.200.55-0.15proteinmRNASCNVmethylationLUAD0.370.030.30-0.020.680.02proteinmRNASCNVmethylationOV0.610.230.52proteinmRNASCNVmethylationPDAC0.360.040.230.070.44-0.14proteinmRNASCNVmethylationUCEC0.46-0.010.13-0.100.11-0.05proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of AP4E1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.