Basic information

Full name
bromodomain containing 2
Ensembl
ENSG00000204256.13
Summary
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
Annotation
Druggable target (Tier T3) Protein Kinase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.12-0.037--0.2-0.075-0.064--1.5e-3-
protein5.9e-45-5.6e-63.6e-11-2.9e-96.3e-321.5e-180.011-0.77-0.92

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC10.81111.211.411.611.81212.212.412.612.81313.213.413.613.8log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2222.52323.52424.52525.526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of BRD2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_G2M_CHECKPOINT7.1e-391.9e-40.431.1e-52.8e-82.2e-162.2e-162.3e-30.0780.576.2e-7
HALLMARK_E2F_TARGETS4.7e-361.4e-5-0.417.2e-63.9e-82.2e-162.2e-161.4e-30.120.442.5e-5
HALLMARK_MYC_TARGETS_V28.4e-251.3e-4-0.113.5e-33.3e-69.2e-52.2e-168.6e-30.0470.0742.4e-5
KINASE-PSP_CDK21.8e-227.1e-5-0.822.4e-38.6e-81.1e-71.6e-66.2e-4-0.50.131.4e-5
HALLMARK_SPERMATOGENESIS5e-226.9e-7-0.495.3e-40.0714e-102.2e-162.5e-50.560.770.16
xcell: T cell CD4+ Th13.1e-212.3e-50.170.0834.2e-73.9e-41.6e-85.2e-30.0450.20.026
HALLMARK_DNA_REPAIR1.3e-201.2e-4-0.484.9e-32.4e-41.1e-42.2e-160.0240.0550.838.4e-4
Tumor Purity (WGS)2.2e-15--0.75-1.8e-71.6e-55.9e-140.16-0.320.062
HALLMARK_MYC_TARGETS_V16e-151.3e-3-0.150.0223.1e-49.4e-31.9e-102.4e-30.070.110.11
KINASE-PSP_CK2A1/CSNK2A17.8e-144.7e-3-0.366.5e-31.3e-32.2e-161.9e-30.45-0.610.0890.012
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of BRD2

BRCA0.330.360.27proteinmRNASCNVmethylationCCRCC0.490.020.17-0.140.41-0.18proteinmRNASCNVmethylationCOAD0.290.200.47proteinmRNASCNVmethylationGBM0.40-0.020.18-0.080.380.03proteinmRNASCNVmethylationHNSCC0.27-0.020.16-0.280.48-0.34proteinmRNASCNVmethylationLSCC0.55-0.070.33-0.180.64-0.37proteinmRNASCNVmethylationLUAD0.47-0.010.30-0.090.600.02proteinmRNASCNVmethylationOV0.400.250.65proteinmRNASCNVmethylationPDAC0.180.040.20-0.020.53-0.22proteinmRNASCNVmethylationUCEC0.510.070.19-0.190.30-0.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of BRD2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.