Basic information

Full name
cell division cycle 23
Ensembl
ENSG00000094880.11
Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.6e-34-2.2e-18--2.5e-31.1e-99.9e-10-6.1e-4-
protein6.7e-28-9.8e-181.0e-5-1.2e-116.5e-79.4e-90.16-2.2e-30.033

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC21.52222.52323.52424.525log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CDC23 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETS1.1e-140.0440.077-0.373.2e-52.0e-42.4e-49.7e-30.554.8e-50.006
HALLMARK_G2M_CHECKPOINT9.3e-130.150.67-0.411.0e-53.2e-32.2e-49.2e-30.21.4e-45.2e-3
HALLMARK_MYC_TARGETS_V21.1e-120.0210.41-0.392.4e-52.8e-36.4e-70.02-0.734.7e-31.2e-3
HALLMARK_MYC_TARGETS_V17.7e-127.2e-30.13-0.336.3e-32.6e-45.7e-40.0440.876.2e-32.5e-4
xcell: T cell CD4+ Th21.2e-100.390.04-7.9e-31.0e-60.0368.1e-43.2e-30.361.3e-37.4e-3
KINASE-PSP_CDK22.9e-100.730.32-0.251.2e-36.0e-67.4e-30.0190.341.1e-50.11
HALLMARK_DNA_REPAIR9.4e-100.0220.22-0.044.9e-51.5e-42.8e-40.019-0.950.0110.11
KINASE-PSP_CDK14.5e-9-0.98-0.62-0.591.8e-41.4e-41.4e-30.0540.493.9e-60.1
HALLMARK_MITOTIC_SPINDLE5.9e-90.21-0.360.111.0e-40.0464.4e-49.7e-30.844.4e-30.15
xcell: T cell CD4+ Th11.1e-89.1e-40.90.397.1e-40.0110.0140.290.610.110.027
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CDC23

BRCA0.220.090.23proteinmRNASCNVmethylationCCRCC0.480.280.57proteinmRNASCNVmethylationCOAD-0.050.060.26proteinmRNASCNVmethylationGBM0.460.050.20proteinmRNASCNVmethylationHNSCC0.320.060.58proteinmRNASCNVmethylationLSCC0.420.030.42proteinmRNASCNVmethylationLUAD0.17-0.060.63proteinmRNASCNVmethylationOV0.270.180.46proteinmRNASCNVmethylationPDAC0.160.120.34proteinmRNASCNVmethylationUCEC0.340.250.13proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CDC23 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.